GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

N. R. Sims; C. C.T. Smith; A. N. Davison; D. M. Bowen; R. H.A. Flack; J. S. Snowden; D. Neary

doi:10.1016/S0140-6736(80)90884-3

GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

N. R. Sims, C. C.T. Smith, A. N. Davison, D. M. Bowen, R. H.A. Flack, J. S. Snowden, D. Neary

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Abstract

The metabolism of (U-¹⁴C) glucose and its incorporation into acetylcholine were determined in vitro in fresh cortical biopsy samples from patients with Alzheimer's disease and controls. Synthesis of ¹⁴C acetylcholine was significantly reduced (60% and 67% reduction under stimulated and resting conditions, respectively) without significant changes in the overall metabolism of glucose (as measured by ¹⁴CO₂ production). Acetylcholine synthesis was directly related to the activity of choline acetyltransferase. The changes in cholinergic markers reflected the severity of psychological defects. Acetylcholine synthesis was not reduced in biopsy samples from patients suffering from presenile dementia with no histological evidence of Alzheimer's disease.

Original language	English
Pages (from-to)	333-336
Number of pages	4
Journal	The Lancet
Volume	315
Issue number	8164
DOIs	https://doi.org/10.1016/S0140-6736(80)90884-3
Publication status	Published - 16 Feb 1980
Externally published	Yes

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title = "GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE",

abstract = "The metabolism of (U-14C) glucose and its incorporation into acetylcholine were determined in vitro in fresh cortical biopsy samples from patients with Alzheimer's disease and controls. Synthesis of 14C acetylcholine was significantly reduced (60% and 67% reduction under stimulated and resting conditions, respectively) without significant changes in the overall metabolism of glucose (as measured by 14CO2 production). Acetylcholine synthesis was directly related to the activity of choline acetyltransferase. The changes in cholinergic markers reflected the severity of psychological defects. Acetylcholine synthesis was not reduced in biopsy samples from patients suffering from presenile dementia with no histological evidence of Alzheimer's disease.",

author = "Sims, {N. R.} and Smith, {C. C.T.} and Davison, {A. N.} and Bowen, {D. M.} and Flack, {R. H.A.} and Snowden, {J. S.} and D. Neary",

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AU - Sims, N. R.

AU - Smith, C. C.T.

AU - Davison, A. N.

AU - Bowen, D. M.

AU - Flack, R. H.A.

AU - Snowden, J. S.

AU - Neary, D.

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N2 - The metabolism of (U-14C) glucose and its incorporation into acetylcholine were determined in vitro in fresh cortical biopsy samples from patients with Alzheimer's disease and controls. Synthesis of 14C acetylcholine was significantly reduced (60% and 67% reduction under stimulated and resting conditions, respectively) without significant changes in the overall metabolism of glucose (as measured by 14CO2 production). Acetylcholine synthesis was directly related to the activity of choline acetyltransferase. The changes in cholinergic markers reflected the severity of psychological defects. Acetylcholine synthesis was not reduced in biopsy samples from patients suffering from presenile dementia with no histological evidence of Alzheimer's disease.

AB - The metabolism of (U-14C) glucose and its incorporation into acetylcholine were determined in vitro in fresh cortical biopsy samples from patients with Alzheimer's disease and controls. Synthesis of 14C acetylcholine was significantly reduced (60% and 67% reduction under stimulated and resting conditions, respectively) without significant changes in the overall metabolism of glucose (as measured by 14CO2 production). Acetylcholine synthesis was directly related to the activity of choline acetyltransferase. The changes in cholinergic markers reflected the severity of psychological defects. Acetylcholine synthesis was not reduced in biopsy samples from patients suffering from presenile dementia with no histological evidence of Alzheimer's disease.

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GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

Abstract

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