Glutamate in spinally projecting neurons of the rostral ventral medulla

Jane Minson; Paul Pilowsky; Ida Llewellyn-Smith; Takeshi Kaneko; Vimal Kapoor; John Chalmers

doi:10.1016/0006-8993(91)90359-4

Glutamate in spinally projecting neurons of the rostral ventral medulla

Jane Minson, Paul Pilowsky, Ida Llewellyn-Smith, Takeshi Kaneko, Vimal Kapoor, John Chalmers

Research output: Contribution to journal › Article › peer-review

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Abstract

Phosphate activated glutaminase (PAG), an enzyme of glutamate synthesis, was localized by immunohistochemistry in all PNMT-immunoreactive and all serotonin-immunoreactive neurons in the rostral ventral medulla of the rat. Between 71 and 83% of bulbospinal neurons localised in the rostral ventral medulla projecting to the intermediolateral cell column in the upper thoracic spinal cord contained PAG immunoreactivity. Of these bulbospinal PAG-immunoreactive neurons 17-27% contained PNMT immunoreactivity and 9-16% contained serotonin immunoreactivity. Other bulbospinal PAG-immunoreactive neurons (60-70%) contained neither PNMT- nor serotonin immunoreactivity. The results provide anatomical evidence suggestive of a glutamatergic input to the sympathetic preganglionic neurons of the spinal cord arising from different populations of neurons located in the rostral ventral medulla.

Original language	English
Pages (from-to)	326-331
Number of pages	6
Journal	Brain Research
Volume	555
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90359-4
Publication status	Published - 2 Aug 1991

Keywords

Bulbospinal
Cholera toxin B
Phosphate activated glutaminase
PNMT
Rat
Rostral ventrolateral medulla
Serotonin
Sympathetic preganglionic neuron

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title = "Glutamate in spinally projecting neurons of the rostral ventral medulla",

abstract = "Phosphate activated glutaminase (PAG), an enzyme of glutamate synthesis, was localized by immunohistochemistry in all PNMT-immunoreactive and all serotonin-immunoreactive neurons in the rostral ventral medulla of the rat. Between 71 and 83% of bulbospinal neurons localised in the rostral ventral medulla projecting to the intermediolateral cell column in the upper thoracic spinal cord contained PAG immunoreactivity. Of these bulbospinal PAG-immunoreactive neurons 17-27% contained PNMT immunoreactivity and 9-16% contained serotonin immunoreactivity. Other bulbospinal PAG-immunoreactive neurons (60-70%) contained neither PNMT- nor serotonin immunoreactivity. The results provide anatomical evidence suggestive of a glutamatergic input to the sympathetic preganglionic neurons of the spinal cord arising from different populations of neurons located in the rostral ventral medulla.",

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author = "Jane Minson and Paul Pilowsky and Ida Llewellyn-Smith and Takeshi Kaneko and Vimal Kapoor and John Chalmers",

year = "1991",

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doi = "10.1016/0006-8993(91)90359-4",

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T1 - Glutamate in spinally projecting neurons of the rostral ventral medulla

AU - Minson, Jane

AU - Pilowsky, Paul

AU - Llewellyn-Smith, Ida

AU - Kaneko, Takeshi

AU - Kapoor, Vimal

AU - Chalmers, John

PY - 1991/8/2

Y1 - 1991/8/2

N2 - Phosphate activated glutaminase (PAG), an enzyme of glutamate synthesis, was localized by immunohistochemistry in all PNMT-immunoreactive and all serotonin-immunoreactive neurons in the rostral ventral medulla of the rat. Between 71 and 83% of bulbospinal neurons localised in the rostral ventral medulla projecting to the intermediolateral cell column in the upper thoracic spinal cord contained PAG immunoreactivity. Of these bulbospinal PAG-immunoreactive neurons 17-27% contained PNMT immunoreactivity and 9-16% contained serotonin immunoreactivity. Other bulbospinal PAG-immunoreactive neurons (60-70%) contained neither PNMT- nor serotonin immunoreactivity. The results provide anatomical evidence suggestive of a glutamatergic input to the sympathetic preganglionic neurons of the spinal cord arising from different populations of neurons located in the rostral ventral medulla.

AB - Phosphate activated glutaminase (PAG), an enzyme of glutamate synthesis, was localized by immunohistochemistry in all PNMT-immunoreactive and all serotonin-immunoreactive neurons in the rostral ventral medulla of the rat. Between 71 and 83% of bulbospinal neurons localised in the rostral ventral medulla projecting to the intermediolateral cell column in the upper thoracic spinal cord contained PAG immunoreactivity. Of these bulbospinal PAG-immunoreactive neurons 17-27% contained PNMT immunoreactivity and 9-16% contained serotonin immunoreactivity. Other bulbospinal PAG-immunoreactive neurons (60-70%) contained neither PNMT- nor serotonin immunoreactivity. The results provide anatomical evidence suggestive of a glutamatergic input to the sympathetic preganglionic neurons of the spinal cord arising from different populations of neurons located in the rostral ventral medulla.

KW - Bulbospinal

KW - Cholera toxin B

KW - Phosphate activated glutaminase

KW - PNMT

KW - Rat

KW - Rostral ventrolateral medulla

KW - Serotonin

KW - Sympathetic preganglionic neuron

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DO - 10.1016/0006-8993(91)90359-4

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AN - SCOPUS:0025775665

SN - 0006-8993

VL - 555

SP - 326

EP - 331

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Glutamate in spinally projecting neurons of the rostral ventral medulla

Abstract

Keywords

UN SDGs

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