TY - JOUR
T1 - Glutathione peroxidase in stable chronic obstructive pulmonary disease
T2 - A systematic review and meta-analysis
AU - Zinellu, Elisabetta
AU - Zinellu, Angelo
AU - Pau, Maria Carmina
AU - Piras, Barbara
AU - Fois, Alessandro G.
AU - Mellino, Sabrina
AU - Carru, Ciriaco
AU - Mangoni, Arduino A.
AU - Pirina, Pietro
PY - 2021/11
Y1 - 2021/11
N2 - Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, p < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.
AB - Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, p < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.
KW - Antioxidant defense systems
KW - Chronic obstructive pulmonary disease
KW - Glutathione peroxidase
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85118226464&partnerID=8YFLogxK
U2 - 10.3390/antiox10111745
DO - 10.3390/antiox10111745
M3 - Review article
AN - SCOPUS:85118226464
SN - 2076-3921
VL - 10
JO - Antioxidants
JF - Antioxidants
IS - 11
M1 - 1745
ER -