Glutathione peroxidase in stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Elisabetta Zinellu, Angelo Zinellu, Maria Carmina Pau, Barbara Piras, Alessandro G. Fois, Sabrina Mellino, Ciriaco Carru, Arduino A. Mangoni, Pietro Pirina

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, p < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.

Original languageEnglish
Article number1745
Number of pages16
JournalAntioxidants
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Antioxidant defense systems
  • Chronic obstructive pulmonary disease
  • Glutathione peroxidase
  • Oxidative stress

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