Glycine receptor α2 subunit activation promotes cortical interneuron migration

Ariel Avila, Pía Vidal, T Dear, Robert Harvey, Jean-Michel Rigo, Laurent Nguyen

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons invivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis

    Original languageEnglish
    Pages (from-to)738-750
    Number of pages13
    JournalCell Reports
    Volume4
    Issue number4
    DOIs
    Publication statusPublished - 29 Aug 2013

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  • Cite this

    Avila, A., Vidal, P., Dear, T., Harvey, R., Rigo, J-M., & Nguyen, L. (2013). Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell Reports, 4(4), 738-750. https://doi.org/10.1016/j.celrep.2013.07.016