Graphene oxide decorated diatom silica particles as new nano-hybrids: towards smart natural drug microcarriers

Tushar Kumeria, Manpreet Bariana, Tariq Altalhi, Mahaveer Kurkuri, Christopher Gibson, Wenrong Yang, Dusan Losic

    Research output: Contribution to journalArticlepeer-review

    89 Citations (Scopus)


    Herein, we demonstrate the fabrication of a novel nano-hybrid material based on diatom silica microparticles from diatomaceous earth (DE) and graphene oxide (GO). Two different approaches for the fabrication of nano-hybrids were used, including covalent coupling of GO sheets onto the diatom surface and electrostatic attachment. Covalent attachment was carried out through a facile amine coupling strategy via activation of carboxyl groups on GO, followed by covalent attachment to amine terminal groups of 3-aminopropyl-triethoxysilane (APTES) functionalized DE particles. Electrostatic attachment of GO (i.e. negatively charged) was carried out on positively charged APTES functionalized DE particles. The GO decorated DE nano-hybrids prepared with both the fabrication processes were extensively characterized by SEM, TEM, FTIR, and Raman spectroscopy to confirm the new chemical composition and structure. The application of the GO-DE nano-hybrid as a smart pH sensitive micro-drug carrier at pH 7.4 and pH 3.5 was demonstrated using a model drug, indomethacin (IMC). Finally, the drug release data were fitted to zero-order and Korsmeyer-Peppas models to understand the mechanism of drug release.

    Original languageEnglish
    Pages (from-to)6302-6311
    Number of pages10
    Issue number45
    Publication statusPublished - 7 Dec 2013


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