TY - JOUR
T1 - Greater endothelial activation, Weibel-Palade body release and host inflammatory response to plasmodium vivax, compared with plasmodium falciparum: A prospective study in Papua, Indonesia
AU - Yeo, Tsin
AU - Lampah, Daniel
AU - Tjitra, E
AU - Piera, Kim
AU - Gitawati, Retno
AU - Kenangalem, E
AU - Price, Ric
AU - Anstey, Nicholas
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.
AB - Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.
UR - http://www.scopus.com/inward/record.url?scp=77953716338&partnerID=8YFLogxK
U2 - 10.1086/653211
DO - 10.1086/653211
M3 - Article
SN - 0022-1899
VL - 202
SP - 109
EP - 112
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -