Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

P Zheng, B Zeng, C Zhou, M Liu, Z Fang, X Xu, L Zeng, J Chen, S Fan, X Du, X Du, X Zhang, D Yang, Y Yang, H Meng, W Li, D Melgiri, Julio Licinio, H Wei, P Xie

    Research output: Contribution to journalArticle

    501 Citations (Scopus)

    Abstract

    Major depressive disorder (MDD) is the result of complex gene-environment interactions. According to the World Health Organization, MDD is the leading cause of disability worldwide, and it is a major contributor to the overall global burden of disease. However, the definitive environmental mechanisms underlying the pathophysiology of MDD remain elusive. The gut microbiome is an increasingly recognized environmental factor that can shape the brain through the microbiota-gut-brain axis. We show here that the absence of gut microbiota in germ-free (GF) mice resulted in decreased immobility time in the forced swimming test relative to conventionally raised healthy control mice. Moreover, from clinical sampling, the gut microbiotic compositions of MDD patients and healthy controls were significantly different with MDD patients characterized by significant changes in the relative abundance of Firmicutes, Actinobacteria and Bacteroidetes. Fecal microbiota transplantation of GF mice with 'depression microbiota' derived from MDD patients resulted in depression-like behaviors compared with colonization with 'healthy microbiota' derived from healthy control individuals. Mice harboring 'depression microbiota' primarily exhibited disturbances of microbial genes and host metabolites involved in carbohydrate and amino acid metabolism. This study demonstrates that dysbiosis of the gut microbiome may have a causal role in the development of depressive-like behaviors, in a pathway that is mediated through the host's metabolism.

    Original languageEnglish
    Pages (from-to)786-796
    Number of pages11
    JournalMOLECULAR PSYCHIATRY
    Volume21
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2016

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