Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the ‘gut pain’ pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.
- ‘gut pain’ pathway
- intestinal bacterial pathogens
- pathogen colonization