Gut nociceptors: sentinels promoting host defense

Research output: Contribution to journalComment/debate

Abstract

Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the ‘gut pain’ pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.
Original languageEnglish
Pages (from-to)279-280
Number of pages2
JournalCELL RESEARCH
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2020

Keywords

  • ‘gut pain’ pathway
  • intestinal bacterial pathogens
  • pathogen colonization

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