Gut nociceptors: sentinels promoting host defense

Stuart M. Brierley

doi:10.1038/s41422-020-0278-9

Gut nociceptors: sentinels promoting host defense

Stuart M. Brierley

College of Medicine and Public Health

Research output: Contribution to journal › Comment/debate

2 Citations (Scopus)

Abstract

Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the ‘gut pain’ pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.

Original language	English
Pages (from-to)	279-280
Number of pages	2
Journal	CELL RESEARCH
Volume	30
Issue number	4
DOIs	https://doi.org/10.1038/s41422-020-0278-9
Publication status	Published - Apr 2020

Keywords

‘gut pain’ pathway
intestinal bacterial pathogens
pathogen colonization

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title = "Gut nociceptors: sentinels promoting host defense",

abstract = "Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the {\textquoteleft}gut pain{\textquoteright} pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.",

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AB - Gut-innervating nociceptive neurons detect noxious mechanical and chemical stimuli within our gut, constituting the start of the ‘gut pain’ pathway. In a recent paper in Cell, Lai et al. report that these nociceptors also play major roles in sensing intestinal bacterial pathogens as well as defending the host by limiting pathogen colonization and invasion.

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KW - pathogen colonization

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Gut nociceptors: sentinels promoting host defense

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Keywords

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