Hairless promotes PPARγ expression and is required for white adipogenesis

Susann Kumpf, Michael Mihlan, Alexander Goginashvili, Gerald Grandl, Helmuth Gehart, Aurélie Godel, Juliane Schmidt, Julius Müller, Marco Bezzi, Arne Ittner, Ernesto Guccione, Christian Wolfrum, Romeo Ricci

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Adipose tissue is the largest compartment in the mammalian body for storing energy as fat, providing an important reservoir of fuel for maintaining whole body energy homeostasis. Herein, we identify the transcriptional cofactor hairless (HR) to be required for white adipogenesis. Moreover, forced expression of HR in non-Adipogenic precursor cells induces adipogenic gene expression and enhances adipocyte formation under permissive conditions. HR exerts its proadipogenic effects by regulating the expression of PPARγ, one of the central adipogenic transcription factors. In conclusion, our data provide a new mechanism required for white adipogenesis.

Original languageEnglish
Pages (from-to)1012-1020
Number of pages9
JournalEMBO REPORTS
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Nov 2012
Externally publishedYes

Keywords

  • adipogenesis
  • hairless
  • JmjC
  • obesity
  • PPARγ

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