Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman, Matthew Collier, Bram Frohock, Michael Womble, Justin Chalker

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

    Original languageEnglish
    Pages (from-to)1974-1978
    Number of pages5
    JournalOrganic and Biomolecular Chemistry
    Volume13
    Issue number7
    DOIs
    Publication statusPublished - 21 Feb 2015

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