Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman; Matthew Collier; Bram Frohock; Michael Womble; Justin Chalker

doi:10.1039/c4ob02479f

Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman, Matthew Collier, Bram Frohock, Michael Womble, Justin Chalker

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

Original language	English
Pages (from-to)	1974-1978
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	7
DOIs	https://doi.org/10.1039/c4ob02479f
Publication status	Published - 21 Feb 2015

Access to Document

10.1039/c4ob02479f

Cite this

@article{b225a00d2b1e4053adddfae147f63cae,

title = "Halide inhibition of the copper-catalysed azide-alkyne cycloaddition",

abstract = "Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is",

author = "Rebekah Moorman and Matthew Collier and Bram Frohock and Michael Womble and Justin Chalker",

year = "2015",

month = feb,

day = "21",

doi = "10.1039/c4ob02479f",

language = "English",

volume = "13",

pages = "1974--1978",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

AU - Moorman, Rebekah

AU - Collier, Matthew

AU - Frohock, Bram

AU - Womble, Michael

AU - Chalker, Justin

PY - 2015/2/21

Y1 - 2015/2/21

N2 - Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

AB - Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84922681018&partnerID=8YFLogxK

U2 - 10.1039/c4ob02479f

DO - 10.1039/c4ob02479f

M3 - Article

SN - 1477-0520

VL - 13

SP - 1974

EP - 1978

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Abstract

Access to Document

Other files and links

Fingerprint

Cite this