Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman; Matthew Collier; Bram Frohock; Michael Womble; Justin Chalker

doi:10.1039/c4ob02479f

Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman, Matthew Collier, Bram Frohock, Michael Womble, Justin Chalker

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

Original language	English
Pages (from-to)	1974-1978
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	7
DOIs	https://doi.org/10.1039/c4ob02479f
Publication status	Published - 21 Feb 2015

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Moorman, R., Collier, M., Frohock, B., Womble, M., & Chalker, J. (2015). Halide inhibition of the copper-catalysed azide-alkyne cycloaddition. Organic and Biomolecular Chemistry, 13(7), 1974-1978. https://doi.org/10.1039/c4ob02479f

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AB - Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

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