Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman; Matthew Collier; Bram Frohock; Michael Womble; Justin Chalker

doi:10.1039/c4ob02479f

Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Rebekah Moorman
, Matthew Collier
, Bram Frohock
, Michael Womble
, Justin Chalker

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

Original language	English
Pages (from-to)	1974-1978
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	7
DOIs	https://doi.org/10.1039/c4ob02479f
Publication status	Published - 21 Feb 2015

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title = "Halide inhibition of the copper-catalysed azide-alkyne cycloaddition",

abstract = "Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is",

author = "Rebekah Moorman and Matthew Collier and Bram Frohock and Michael Womble and Justin Chalker",

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T1 - Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

AU - Moorman, Rebekah

AU - Collier, Matthew

AU - Frohock, Bram

AU - Womble, Michael

AU - Chalker, Justin

PY - 2015/2/21

Y1 - 2015/2/21

N2 - Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

AB - Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction. This journal is

UR - https://www.scopus.com/pages/publications/84922681018

U2 - 10.1039/c4ob02479f

DO - 10.1039/c4ob02479f

M3 - Article

SN - 1477-0520

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SP - 1974

EP - 1978

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

Abstract

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