Harnessing Thin-Film Continuous-Flow Assembly Lines

Joshua Britton, Jared Castle, Gregory Weiss, Colin Raston

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Inspired by nature's ability to construct complex molecules through sequential synthetic transformations, an assembly line synthesis of α-aminophosphonates has been developed. In this approach, simple starting materials are continuously fed through a thin-film reactor where the intermediates accrue molecular complexity as they progress through the flow system. Flow chemistry allows rapid multistep transformations to occur via reaction compartmentalization, an approach not amenable to using conventional flasks. Thin film processing can also access facile in situ solvent exchange to drive reaction efficiency, and through this method, α-aminophosphonate synthesis requires only 443 s residence time to produce 3.22 g h−1. Assembly-line synthesis allows unprecedented reaction flexibility and processing efficiency.

    Original languageEnglish
    Pages (from-to)10773-10776
    Number of pages4
    JournalChemistry-A European Journal
    Volume22
    Issue number31
    DOIs
    Publication statusPublished - 25 Jul 2016

    Keywords

    • continuous-flow chemistry
    • multistep transformations
    • reaction telescoping
    • thin films
    • α-aminophosphonates

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