Health-related quality of life (Hrqol) outcomes following injury in childhood and adolescence using euroqol (eq-5d) responses with pooled longitudinal data

Joanna F. Dipnall, Frederick P. Rivara, Ronan A. Lyons, Shanthi Ameratunga, Mariana Brussoni, Fiona E. Lecky, Clare Bradley, Ben Beck, Jane Lyons, Amy Schneeberg, James E. Harrison, Belinda J. Gabbe

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5– 17 years) at baseline, 1-, 4-, 6-, 12-, and 24-months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.

Original languageEnglish
Article number10156
Number of pages19
JournalInternational Journal of Environmental Research and Public Health
Volume18
Issue number19
DOIs
Publication statusPublished - 1 Oct 2021

Keywords

  • Adolescents
  • Children
  • Disability
  • EQ-5D
  • Health outcomes
  • Health-related quality of life
  • Injury
  • Pediatric
  • Trauma

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