TY - JOUR
T1 - Health-related quality of life (Hrqol) outcomes following injury in childhood and adolescence using euroqol (eq-5d) responses with pooled longitudinal data
AU - Dipnall, Joanna F.
AU - Rivara, Frederick P.
AU - Lyons, Ronan A.
AU - Ameratunga, Shanthi
AU - Brussoni, Mariana
AU - Lecky, Fiona E.
AU - Bradley, Clare
AU - Beck, Ben
AU - Lyons, Jane
AU - Schneeberg, Amy
AU - Harrison, James E.
AU - Gabbe, Belinda J.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5– 17 years) at baseline, 1-, 4-, 6-, 12-, and 24-months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.
AB - Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5– 17 years) at baseline, 1-, 4-, 6-, 12-, and 24-months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.
KW - Adolescents
KW - Children
KW - Disability
KW - EQ-5D
KW - Health outcomes
KW - Health-related quality of life
KW - Injury
KW - Pediatric
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=85115749637&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1142325
UR - http://purl.org/au-research/grants/ARC/FT170100048
U2 - 10.3390/ijerph181910156
DO - 10.3390/ijerph181910156
M3 - Article
AN - SCOPUS:85115749637
VL - 18
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1660-4601
IS - 19
M1 - 10156
ER -