TY - JOUR
T1 - Health-Related Quality of Life in People Across the Spectrum of CKD
AU - Krishnan, Anoushka
AU - Teixeira-Pinto, Armando
AU - Lim, Wai H.
AU - Howard, Kirsten
AU - Chapman, Jeremy R.
AU - Castells, Antoni
AU - Roger, Simon D.
AU - Bourke, Michael J.
AU - Macaskill, Petra
AU - Williams, Gabrielle
AU - Lok, Charmaine E.
AU - Diekmann, Fritz
AU - Cross, Nicholas
AU - Sen, Shaundeep
AU - Allen, Richard D.M.
AU - Chadban, Steven J.
AU - Pollock, Carol A.
AU - Turner, Robin
AU - Tong, Allison
AU - Yang, Jean Y.H.
AU - Williams, Narelle
AU - Au, Eric
AU - Kieu, Anh
AU - James, Laura
AU - Francis, Anna
AU - Wong, Germaine
AU - Craig, Jonathan C.
PY - 2020/12
Y1 - 2020/12
N2 - Introduction: People with chronic kidney disease (CKD) experience reduced quality of life (QoL) because of the high symptom and treatment burden. Limited data exist on the factors associated with overall and domain-specific QoL across all CKD stages. Methods: Using data from a prospective, multinational study (Australia, New Zealand, Canada, and Spain) in 1696 participants with CKD, we measured overall and domain-specific QoL (pain, self-care, activity, mobility, anxiety/depression) using the EuroQoL, 5 dimension, 3 level. Multivariable linear regression and logistic modeling were used to determine factors associated with overall and domain-specific QoL. Results: QoL for patients with CKD stages 3 to 5 (n = 787; mean, 0.81; SD, 0.20) was higher than in patients on dialysis (n = 415; mean, 0.76; SD, 0.24) but lower than in kidney transplant recipients (n = 494; mean, 0.84; SD, 0.21). Factors associated with reduced overall QoL (β [95% confidence intervals]) included being on dialysis (compared with CKD stages 3–5: –0.06 [–0.08 to –0.03]), female sex (–0.03 [–0.05 to –0.006]), lower educational attainment (– 0.04 [–0.06 to –0.02), lacking a partner (–0.04 [–0.06 to –0.02]), having diabetes (–0.05 [–0.07 to –0.02]), history of stroke (–0.09 [–0.13 to –0.05]), cardiovascular disease (–0.06 [–0.08 to –0.03]), and cancer (–0.03 [–0.06 to –0.009]). Pain (43%) and anxiety/depression (30%) were the most commonly affected domains, with dialysis patients reporting decrements in all 5 domains. Predictors for domain-specific QoL included being on dialysis, presence of comorbidities, lower education, female sex, and lack of a partner. Conclusions: Being on dialysis, women with CKD, those with multiple comorbidities, lack of a partner, and lower educational attainment were associated with lower QoL across all stages of CKD.
AB - Introduction: People with chronic kidney disease (CKD) experience reduced quality of life (QoL) because of the high symptom and treatment burden. Limited data exist on the factors associated with overall and domain-specific QoL across all CKD stages. Methods: Using data from a prospective, multinational study (Australia, New Zealand, Canada, and Spain) in 1696 participants with CKD, we measured overall and domain-specific QoL (pain, self-care, activity, mobility, anxiety/depression) using the EuroQoL, 5 dimension, 3 level. Multivariable linear regression and logistic modeling were used to determine factors associated with overall and domain-specific QoL. Results: QoL for patients with CKD stages 3 to 5 (n = 787; mean, 0.81; SD, 0.20) was higher than in patients on dialysis (n = 415; mean, 0.76; SD, 0.24) but lower than in kidney transplant recipients (n = 494; mean, 0.84; SD, 0.21). Factors associated with reduced overall QoL (β [95% confidence intervals]) included being on dialysis (compared with CKD stages 3–5: –0.06 [–0.08 to –0.03]), female sex (–0.03 [–0.05 to –0.006]), lower educational attainment (– 0.04 [–0.06 to –0.02), lacking a partner (–0.04 [–0.06 to –0.02]), having diabetes (–0.05 [–0.07 to –0.02]), history of stroke (–0.09 [–0.13 to –0.05]), cardiovascular disease (–0.06 [–0.08 to –0.03]), and cancer (–0.03 [–0.06 to –0.009]). Pain (43%) and anxiety/depression (30%) were the most commonly affected domains, with dialysis patients reporting decrements in all 5 domains. Predictors for domain-specific QoL included being on dialysis, presence of comorbidities, lower education, female sex, and lack of a partner. Conclusions: Being on dialysis, women with CKD, those with multiple comorbidities, lack of a partner, and lower educational attainment were associated with lower QoL across all stages of CKD.
KW - chronic kidney disease
KW - domain-specific QoL
KW - EuroQoL-5D3L
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85096846143&partnerID=8YFLogxK
U2 - 10.1016/j.ekir.2020.09.028
DO - 10.1016/j.ekir.2020.09.028
M3 - Article
AN - SCOPUS:85096846143
VL - 5
SP - 2264
EP - 2274
JO - Kidney International Reports
JF - Kidney International Reports
SN - 2468-0249
IS - 12
ER -