Heck arylation of the natural pyrethrins

Todd E. Markham, Peter J. Duggan, Martin R. Johnston

Research output: Contribution to journalArticlepeer-review


The natural pyrethrins have served as reliable active ingredients in insecticidal formulations and remain ideal due to their environmentally friendly characteristics. This work focussed on the elaboration of the pyrethrin scaffold utilising the palladium catalysed Heck reaction. Utilisation of cationic reaction conditions led to the production of 24 arylated pyrethrin derivatives with a range of substituted aromatic moieties containing (E,E) geometry of the rethrolone side chain.

Original languageEnglish
Article number133160
Number of pages11
Publication statusPublished - 9 Jan 2023


  • Heck arylation
  • Insecticidal activity
  • Pyrethrins


Dive into the research topics of 'Heck arylation of the natural pyrethrins'. Together they form a unique fingerprint.

Cite this