Heck arylation of the natural pyrethrins

Todd E. Markham; Peter J. Duggan; Martin R. Johnston

doi:10.1016/j.tet.2022.133160

Heck arylation of the natural pyrethrins

Todd E. Markham, Peter J. Duggan, Martin R. Johnston

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The natural pyrethrins have served as reliable active ingredients in insecticidal formulations and remain ideal due to their environmentally friendly characteristics. This work focussed on the elaboration of the pyrethrin scaffold utilising the palladium catalysed Heck reaction. Utilisation of cationic reaction conditions led to the production of 24 arylated pyrethrin derivatives with a range of substituted aromatic moieties containing (E,E) geometry of the rethrolone side chain.

Original language	English
Article number	133160
Number of pages	11
Journal	Tetrahedron
Volume	130
DOIs	https://doi.org/10.1016/j.tet.2022.133160
Publication status	Published - 9 Jan 2023

Keywords

Heck arylation
Insecticidal activity
Pyrethrins

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10.1016/j.tet.2022.133160Licence: In Copyright

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Heck arylation of the natural pyrethrins

Abstract

Keywords

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