Helminth induced immunoregulation and novel therapeutic avenue of allergy

Birhanu Ayelign, Yonas Akalu, Banchamlak Teferi, Meseret Derbew Molla, Tewodros Shibabaw

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)
6 Downloads (Pure)

Abstract

Allergic diseases are increasing at an alarming rate worldwide, particularly in developed countries. In contrast, there is a decrease in the prevalence of helminthic infections and other neglected diseases. The hygiene hypothesis elaborates parasitic infec-tion, and allergy-associated diseases have an inverse relationship. Acute helminthic infection and allergic reaction stimulate Type 2 helper cells (Th2) immune response with up-regulation of cytokines IL-4-, IL-5-, and IL-13-mediated IgE and mast cell production, as well as eosinophilia. However, people who chronically suffer from helminthic infections are demar-cated through polarized Th2 resulting in alternative macrophage activation and T regulatory response. This regulatory system reduces allergy incidence in individuals that are chronically diseased through helminth. As a result, the excretory-secretory (ES) substance derived from parasites and extracellular vesicular components can be used as a novel therapeutic modality of allergy. Therefore, the aim of this review meticulously explored the link between helminth infection and allergy, and utilization of the helminth secretome for therapeutic immunomodulation.

Original languageEnglish
Pages (from-to)439-451
Number of pages13
JournalJournal of Asthma and Allergy
Volume13
DOIs
Publication statusPublished - 7 Oct 2020
Externally publishedYes

Keywords

  • Allergy
  • Helminth
  • Hygiene hypothesis
  • IgE
  • Immunotherapy
  • Treg

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