Hereditary influences in oxygen-induced retinopathy in the rat

Peter van Wijngaarden, Helen Brereton, Douglas Coster, Keryn Williams

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Rodent models of oxygen-induced retinopathy (OIR) provide important insights into the pathogenesis of human retinopathy of prematurity. Herein, we present an overview of our work with rat OIR to date. We have identified marked and consistent variations in susceptibility to OIR amongst different inbred rat strains and provide strong evidence for a genetic determinant of susceptibility to OIR. Furthermore, we have characterised differences in retinal angiogenic factor gene expression amongst different inbred rat strains exposed to cyclic hyperoxia. A key determinant of susceptibility to OIR appears to be the extent to which pro-angiogenic factor genes, such as vascular endothelial growth factor and erythropoietin, are expressed during the period of hyperoxic exposure. Those strains in which expression is relatively well maintained are less susceptible to retinopathy than are those in which expression is reduced. In addition, we identify an association between ocular pigmentation and OIR susceptibility.

    Original languageEnglish
    Pages (from-to)87-97
    Number of pages11
    JournalDocumenta Ophthalmologica
    Volume120
    Issue number1
    DOIs
    Publication statusPublished - 2010

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