Abstract
The KCNH2 or human ether-a-go-go related gene (HERG1) encodes the
Kv11.1 protein that is responsible for the rapidly activating delayed rectifier
Kþ current (IKr). Mutations of HERG cause prolongation of cardiac ventricular repolarzation that underlies the long QT syndrome (LQT2) and
associated risk of sudden death. Genetic analyses have identified over 200
LQT2-associated mutations the majority of which impair the exit of
HERG from the endoplasmic reticulum (ER).
Kv11.1 protein that is responsible for the rapidly activating delayed rectifier
Kþ current (IKr). Mutations of HERG cause prolongation of cardiac ventricular repolarzation that underlies the long QT syndrome (LQT2) and
associated risk of sudden death. Genetic analyses have identified over 200
LQT2-associated mutations the majority of which impair the exit of
HERG from the endoplasmic reticulum (ER).
Original language | English |
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Pages (from-to) | 677a |
Number of pages | 1 |
Journal | Biophysical Journal |
Volume | 102 |
Issue number | 3 Suppl 1 |
DOIs | |
Publication status | Published - 31 Jan 2012 |
Externally published | Yes |