hERG Quality Control at the Plasma Membrane

Pirjo Apaja, Tsukasa Okiyondea, Herve Barrière, Hung Lam, Roxana Atanasiu, Brian Foo, Eckhard Ficker, Gergely L. Lukacs, Alvin Shrier

Research output: Contribution to journalArticlepeer-review


The KCNH2 or human ether-a-go-go related gene (HERG1) encodes the
Kv11.1 protein that is responsible for the rapidly activating delayed rectifier
Kþ current (IKr). Mutations of HERG cause prolongation of cardiac ventricular repolarzation that underlies the long QT syndrome (LQT2) and
associated risk of sudden death. Genetic analyses have identified over 200
LQT2-associated mutations the majority of which impair the exit of
HERG from the endoplasmic reticulum (ER).
Original languageEnglish
Pages (from-to)677a
Number of pages1
JournalBiophysical Journal
Issue number3 Suppl 1
Publication statusPublished - 31 Jan 2012
Externally publishedYes


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