Herpes Simplex Virus induces Fos expression in rat brainstem neurons

Z. J. Gieroba; B. S. Zhu; W. W. Blessing; S. L. Wesselingh

doi:10.1016/0006-8993(95)00016-J

Herpes Simplex Virus induces Fos expression in rat brainstem neurons

Z. J. Gieroba, B. S. Zhu, W. W. Blessing, S. L. Wesselingh

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Brain Research
Volume	675
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(95)00016-J
Publication status	Published - 27 Mar 1995

Keywords

Fos
Herpes simplex virus
Medulla oblongata
Vagus nerve

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title = "Herpes Simplex Virus induces Fos expression in rat brainstem neurons",

abstract = "After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.",

keywords = "Fos, Herpes simplex virus, Medulla oblongata, Vagus nerve",

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year = "1995",

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AU - Gieroba, Z. J.

AU - Zhu, B. S.

AU - Blessing, W. W.

AU - Wesselingh, S. L.

PY - 1995/3/27

Y1 - 1995/3/27

N2 - After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.

AB - After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.

KW - Fos

KW - Herpes simplex virus

KW - Medulla oblongata

KW - Vagus nerve

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JF - Brain Research

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ER -

Herpes Simplex Virus induces Fos expression in rat brainstem neurons

Abstract

Keywords

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