TY - JOUR
T1 - Heterotrimetallic Double Cavity Cages
T2 - Syntheses and Selective Guest Binding
AU - Lisboa, Lynn S.
AU - Preston, Dan
AU - McAdam, C. John
AU - Wright, L. James
AU - Hartinger, Christian G.
AU - Crowley, James D.
PY - 2022/4/25
Y1 - 2022/4/25
N2 - A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and PdII ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.
AB - A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and PdII ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.
KW - Double Cavity Cages
KW - Heterometallic
KW - Host–Guest Systems
KW - Metallosupramolecular Architectures
KW - Non-Cooperative Binding
UR - http://www.scopus.com/inward/record.url?scp=85125600130&partnerID=8YFLogxK
U2 - 10.1002/anie.202201700
DO - 10.1002/anie.202201700
M3 - Article
C2 - 35194905
AN - SCOPUS:85125600130
VL - 61
JO - Angewandte Chemie-International Edition
JF - Angewandte Chemie-International Edition
SN - 1433-7851
IS - 18
M1 - e202201700
ER -