Heterotrimetallic Double Cavity Cages: Syntheses and Selective Guest Binding

Lynn S. Lisboa, Dan Preston, C. John McAdam, L. James Wright, Christian G. Hartinger, James D. Crowley

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15 Citations (Scopus)
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A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and PdII ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.

Original languageEnglish
Article numbere202201700
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number18
Publication statusPublished - 25 Apr 2022
Externally publishedYes


  • Double Cavity Cages
  • Heterometallic
  • Host–Guest Systems
  • Metallosupramolecular Architectures
  • Non-Cooperative Binding


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