High Body Mass Index is associated with an expansion of endometrial T Regulatory cell and macrophage populations

Magdalena Palacz, Kelton Tremellen

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Significant positive correlations were observed between BMI and endometrial Treg cells and macrophages, but no relationship with NK cells. We postulate that this change may be a positive adaption to minimise adiposity related inflammation.

    Original languageEnglish
    Pages (from-to)36-39
    Number of pages4
    JournalJOURNAL OF REPRODUCTIVE IMMUNOLOGY
    Volume129
    DOIs
    Publication statusPublished - Sep 2018

    Keywords

    • BMI
    • Endometrial leukocyte
    • Implantation
    • Infertile
    • Macrophage
    • Natural Killer cell
    • NK cell
    • Obesity
    • T regulatory cell
    • Treg cell

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