High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population

Torukiri Ibiebele, Maria Hughes, Nirmala Pandeya, Zhen Zhao, Grant Montgomery, Nicholas Hayward, Adele Green, David Whiteman, Penelope Webb, Peter Parsons, Sandra Pavey, David Purdie, David Gotley, Mark Smithers, Glyn Jamieson, Paul Drew, David Watson, Andrew Clouston, Suzanne O'Brien, Derek NancarrowIan Brown, Suzanne Moore

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Abstract

    Folate plays a key role in DNA synthesis and methylation. Limited evidence suggests high intake may reduce risks of esophageal cancer overall; however, associations with esophageal cancer subtypes and Barrett's esophagus (BE), a precancerous lesion, remain unexplored. We evaluated the relation between intake of folate, B vitamins, and methyl-group donors (methionine, choline, betaine) from foods and supplements, polymorphisms in key folate-metabolizing genes, and risk ofBE, esophageal adenocarcinoma(EAC), andesophageal squamous cell carcinoma (ESCC) in 2 population-basedcase-control studies inAustralia. BE patientswithout (n=266)orwith (n=101) dysplasiawere comparedwith population controls (n=577); similarly, EAC (n = 636) or ESCC (n = 245) patients were compared with population controls (n = 1507) using multivariable adjusted logistic regression. Increasing intake of folate from foods was associated with reduced EAC risk (P-trend = 0.01) and mitigated the increased risks of ESCC associated with smoking and alcohol consumption. In contrast, high intake of folic acid from supplements was associated with a significantly elevated risk of BE with dysplasia. High intakes of riboflavin and methionine from food were associated with increased EAC risk, whereas increasing betaine intake was associated with reduced risks of BE without (P-trend = 0.004) or with dysplasia (P-trend = 0.02). Supplemental thiamin, riboflavin, niacin, and vitamin B-12 were associated with increased EAC risk. There were no consistent associations between genetic polymorphisms studied and BE or EAC risk. High intake of folate-containing foods may reduce risk of EAC, but our data raise the possibility that folic acid supplementation may increase risks of BE with dysplasia and EAC.

    Original languageEnglish
    Pages (from-to)274-283
    Number of pages10
    JournalJournal of Nutrition
    Volume141
    Issue number2
    DOIs
    Publication statusPublished - 2011

    Fingerprint Dive into the research topics of 'High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population'. Together they form a unique fingerprint.

  • Cite this

    Ibiebele, T., Hughes, M., Pandeya, N., Zhao, Z., Montgomery, G., Hayward, N., Green, A., Whiteman, D., Webb, P., Parsons, P., Pavey, S., Purdie, D., Gotley, D., Smithers, M., Jamieson, G., Drew, P., Watson, D., Clouston, A., O'Brien, S., ... Moore, S. (2011). High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population. Journal of Nutrition, 141(2), 274-283. https://doi.org/10.3945/jn.110.131235