High prevalence of late relapse and reinfection in prisoners treated for chronic hepatitis C

John Bate, Anton Colman, Peter Frost, David Shaw, Hugh Harley

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Background and Aim: Prisoners have a high prevalence of injection drug use (IDU) and chronic hepatitis C (CHC) infection. Treatment of CHC in these patients is effective; however, their long-term outcomes following treatment are unknown. We determined the durability of a sustained virological response (SVR) in prisoners treated for CHC. Methods: Patients were treated as part of routine clinical practice with interferon (IFN) and ribavirin. A retrospective review of medical records and a computerized pathology system was performed for clinical and laboratory information. Results: Seventy-four prisoners (70 males, mean age 34 years, IDU in 55%) were evaluable for a SVR over a 12-year period to December 2008; the mean follow-up period was 1243 days. Genotype 1, 2, 3, and 6 infection was present in 18, three, 38 and three patients, respectively; the genotype was unknown in 12. Three out of 52 biopsied had cirrhosis. Standard IFN was administered to 25 (34%; 11 with ribavirin), and 49 received pegylated IFN and ribavirin; one did not complete treatment, and two had breakthrough relapses. The end-of-treatment response was achieved in 57 and SVR in 53; 14 were non-responders. Five male patients, four with unknown genotypes and treated with standard IFN alone, relapsed late (following SVR, 9%). Five patients, all treated with pegylated IFN and ribavirin, were reinfected (one prior to and four following SVR). Conclusions: Prisoners are often successfully treated for CHC. However, this retrospective study indicates that there is a high (17%) prevalence of late recurrence of viremia that is likely a reflection of reinfection due to ongoing risk-taking behavior.

    Original languageEnglish
    Pages (from-to)1276-1280
    Number of pages5
    JournalJournal of Gastroenterology and Hepatology
    Volume25
    Issue number7
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • chronic hepatitis C
    • late relapse
    • prisoners
    • reinfection

    Fingerprint Dive into the research topics of 'High prevalence of late relapse and reinfection in prisoners treated for chronic hepatitis C'. Together they form a unique fingerprint.

    Cite this