High-throughput physicochemical analysis of thermoresponsive polymers

S. J. M. C. Bou, A. R. Connolly, A. V. Ellis

Research output: Contribution to journalArticlepeer-review


Calculating the lower critical solution temperature (LCST) of a thermoresponsive polymer is an important measure of its physical properties. Here, the LCST of poly(N-isopropylacrylamide) (pNIPAM) was determined by measuring the scattered light intensity in a real-time thermocycler. This method allowed for the investigation of low concentration (μg mL−1) samples in low volumes (μL). Subsequently, the critical micelle temperatures (CMTs) and concentrations (CMCs) were simultaneously recorded in 2 h for over 220 samples of the thermoresponsive copolymers of NIPAM with N-hydroxymethyl acrylamide (HMAM) (pNIPAM-co-HMAM (2.5–12.5 mol% HMAM)). This high-throughput approach paves the way to rapidly ‘map’ the physicochemical properties of low abundance polymers with statistical accuracy
Original languageEnglish
Pages (from-to)1934-1937
Number of pages4
JournalPolymer Chemistry
Issue number15
Publication statusPublished - 21 Apr 2018


  • thermoresponsive polymers
  • lower critical solution temperature
  • LCST
  • thermoresponsive


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