HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

Graham Heap; Michael Weedon; Claire Bewshea; Abhey Singh; Mian Chen; Jack Satchwell; Julian Vivian; Kenji So; Patrick Dubois; Jane Andrews; Vito Annese; Peter Bampton; Martin Barnardo; Sally Bell; Andy Cole; Susan Connor; Tom Creed; Fraser Cummings; Mauro D'Amato; Tawfiqu Daneshmend; Richard Fedorak; Timothy Florin; Daniel Gaya; Emma Greig; Jonas Halfvarson; Ailsa Hart; Peter Irving; Gareth Jones; Amir Karban; Ian Lawrance; James Lee; Charlie Lees; Raffi Lev-Tzion; James Lindsay; John Mansfield; Joel Mawdsley; Zia Mazhar; Miles Parkes; Kirstie Parnell; Timothy Orchard; Graham Radford-Smith; Richard Russell; David Reffitt; Jack Satsangi; Mark Silverberg; Giacomo Sturniolo; Mark Tremelling; Epameinondas Tsianos; David van Heel; Alissa Walsh; Gill Watermeyer; Rinse Weersma; Sebastian Zeissig; Jamie Rossjohn; Arthur Holden; Acuth Shenoy; Ahmed Dawood; Alan Ireland; Alan Lobo; Alison Simmons; Alistair McNair; Andre Franke; Andy Bell; Andy Milestone; Anita Modi; Anjan Dhar; Anne Willmott; Anthony Akobeng; Asheesh Sharma; Barney Hawthorne; Basant Chaudhary; Cathryn Edwards; Cathryn Preston; Charles Murray; Charlie Charlton; Chris MacDonald; Colin Jones; Craig Mowat; Daniel Gavin; David Campbell; David Elphick; David Grimes; David Watts; Deb Ghosh; Debasish Das; Deven Vani; Elaine Spalding; Emma Wesley; Gareth Davies; George McFaul; Gill Watts; Guy Chung-Faye; Helen Clarke; Helen Dalal; Ian Gee; James Hart; Jimmy Limdi; Jo Taylor; John Beckly; John Fell; John Gordon; John Green; John Puntis; Jon Simmons; Jonathan Quinlan; Jonathan Snook; Kathleen Holding; Konstantinos Katsanos; Lucy Smyth; Malcolm Smith; Marcus Auth; Marcus Harbord; Marianne Mortimore; Mark Smith; Mark Thomas; Mark Tighe; Matthew Brookes; Melanie Lockett; Michael Delaney; Michael Schultz; Mundre Pradeep; Naomi Edney; Natalie Direkze; Neeraj Prasad; Neil Shah; Nick Croft; Paul Banim; Paul Dunckley; Pierre Ellul; Pradeep Bhandari; Pritash Patel; Rachel Cooney; Rakesh Chaudhary; Rebecca Saich; Renata D'Inca; Richard D'Souza; Richard Felwick; Richard P Pollok; Richard Shenderay; Rosemary Phillips; Sandip Sen; Sean Weaver; Shaji Sebastian; Shani deSilva; Sheldon Cooper; Simon Campbell; Simon Everett; Simon Lal; Simon Panter; Sree Subramanian; Stefan Schreiber; Stephen Foley; Stephen Lewis; Steve Gore; Stuart Bloom; Subramaniam Ramakrishnan; Sue Cullen; Sunil Sonwalker; Suren Kanegasundaram; Tariq Iqbal; Tony Lopez; Vibeke Andersen; Zinu Philipose; Angus Watson; Chris Hawkey; Matt Nelson; Sally John; Jeffrey Waring; Scott Patterson; Bryan Barratt; Joe Walker; Peter Shaw; Steve Lewitzky; Michael Dunn; Tariq Ahmad

doi:10.1038/ng.3093

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

Graham Heap, Michael Weedon, Claire Bewshea, Abhey Singh, Mian Chen, Jack Satchwell, Julian Vivian, Kenji So, Patrick Dubois, Jane Andrews, Vito Annese, Peter Bampton, Martin Barnardo, Sally Bell, Andy Cole, Susan Connor, Tom Creed, Fraser Cummings, Mauro D'Amato, Tawfiqu DaneshmendRichard Fedorak, Timothy Florin, Daniel Gaya, Emma Greig, Jonas Halfvarson, Ailsa Hart, Peter Irving, Gareth Jones, Amir Karban, Ian Lawrance, James Lee, Charlie Lees, Raffi Lev-Tzion, James Lindsay, John Mansfield, Joel Mawdsley, Zia Mazhar, Miles Parkes, Kirstie Parnell, Timothy Orchard, Graham Radford-Smith, Richard Russell, David Reffitt, Jack Satsangi, Mark Silverberg, Giacomo Sturniolo, Mark Tremelling, Epameinondas Tsianos, David van Heel, Alissa Walsh, Gill Watermeyer, Rinse Weersma, Sebastian Zeissig, Jamie Rossjohn, Arthur Holden, Acuth Shenoy, Ahmed Dawood, Alan Ireland, Alan Lobo, Alison Simmons, Alistair McNair, Andre Franke, Andy Bell, Andy Milestone, Anita Modi, Anjan Dhar, Anne Willmott, Anthony Akobeng, Asheesh Sharma, Barney Hawthorne, Basant Chaudhary, Cathryn Edwards, Cathryn Preston, Charles Murray, Charlie Charlton, Chris MacDonald, Colin Jones, Craig Mowat, Daniel Gavin, David Campbell, David Elphick, David Grimes, David Watts, Deb Ghosh, Debasish Das, Deven Vani, Elaine Spalding, Emma Wesley, Gareth Davies, George McFaul, Gill Watts, Guy Chung-Faye, Helen Clarke, Helen Dalal, Ian Gee, James Hart, Jimmy Limdi, Jo Taylor, John Beckly, John Fell, John Gordon, John Green, John Puntis, Jon Simmons, Jonathan Quinlan, Jonathan Snook, Kathleen Holding, Konstantinos Katsanos, Lucy Smyth, Malcolm Smith, Marcus Auth, Marcus Harbord, Marianne Mortimore, Mark Smith, Mark Thomas, Mark Tighe, Matthew Brookes, Melanie Lockett, Michael Delaney, Michael Schultz, Mundre Pradeep, Naomi Edney, Natalie Direkze, Neeraj Prasad, Neil Shah, Nick Croft, Paul Banim, Paul Dunckley, Pierre Ellul, Pradeep Bhandari, Pritash Patel, Rachel Cooney, Rakesh Chaudhary, Rebecca Saich, Renata D'Inca, Richard D'Souza, Richard Felwick, Richard P Pollok, Richard Shenderay, Rosemary Phillips, Sandip Sen, Sean Weaver, Shaji Sebastian, Shani deSilva, Sheldon Cooper, Simon Campbell, Simon Everett, Simon Lal, Simon Panter, Sree Subramanian, Stefan Schreiber, Stephen Foley, Stephen Lewis, Steve Gore, Stuart Bloom, Subramaniam Ramakrishnan, Sue Cullen, Sunil Sonwalker, Suren Kanegasundaram, Tariq Iqbal, Tony Lopez, Vibeke Andersen, Zinu Philipose, Angus Watson, Chris Hawkey, Matt Nelson, Sally John, Jeffrey Waring, Scott Patterson, Bryan Barratt, Joe Walker, Peter Shaw, Steve Lewitzky, Michael Dunn, Tariq Ahmad

Research output: Contribution to journal › Article › peer-review

164 Citations (Scopus)

Abstract

Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 × 10 â '16). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the HLA region identified association with the HLA-DQA1∗02:01-HLA-DRB1∗07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.

Original language	English
Pages (from-to)	1131-1134
Number of pages	4
Journal	Nature Genetics
Volume	46
Issue number	10
DOIs	https://doi.org/10.1038/ng.3093
Publication status	Published - 26 Sept 2014

Access to Document

10.1038/ng.3093

Cite this

Heap, G., Weedon, M., Bewshea, C., Singh, A., Chen, M., Satchwell, J., Vivian, J., So, K., Dubois, P., Andrews, J., Annese, V., Bampton, P., Barnardo, M., Bell, S., Cole, A., Connor, S., Creed, T., Cummings, F., D'Amato, M., ... Ahmad, T. (2014). HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nature Genetics, 46(10), 1131-1134. https://doi.org/10.1038/ng.3093

@article{99218ae61dce4387a604def2fc0f256e,

title = "HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.",

abstract = "Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 × 10 {\^a} '16). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the HLA region identified association with the HLA-DQA1∗02:01-HLA-DRB1∗07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.",

author = "Graham Heap and Michael Weedon and Claire Bewshea and Abhey Singh and Mian Chen and Jack Satchwell and Julian Vivian and Kenji So and Patrick Dubois and Jane Andrews and Vito Annese and Peter Bampton and Martin Barnardo and Sally Bell and Andy Cole and Susan Connor and Tom Creed and Fraser Cummings and Mauro D'Amato and Tawfiqu Daneshmend and Richard Fedorak and Timothy Florin and Daniel Gaya and Emma Greig and Jonas Halfvarson and Ailsa Hart and Peter Irving and Gareth Jones and Amir Karban and Ian Lawrance and James Lee and Charlie Lees and Raffi Lev-Tzion and James Lindsay and John Mansfield and Joel Mawdsley and Zia Mazhar and Miles Parkes and Kirstie Parnell and Timothy Orchard and Graham Radford-Smith and Richard Russell and David Reffitt and Jack Satsangi and Mark Silverberg and Giacomo Sturniolo and Mark Tremelling and Epameinondas Tsianos and {van Heel}, David and Alissa Walsh and Gill Watermeyer and Rinse Weersma and Sebastian Zeissig and Jamie Rossjohn and Arthur Holden and Acuth Shenoy and Ahmed Dawood and Alan Ireland and Alan Lobo and Alison Simmons and Alistair McNair and Andre Franke and Andy Bell and Andy Milestone and Anita Modi and Anjan Dhar and Anne Willmott and Anthony Akobeng and Asheesh Sharma and Barney Hawthorne and Basant Chaudhary and Cathryn Edwards and Cathryn Preston and Charles Murray and Charlie Charlton and Chris MacDonald and Colin Jones and Craig Mowat and Daniel Gavin and David Campbell and David Elphick and David Grimes and David Watts and Deb Ghosh and Debasish Das and Deven Vani and Elaine Spalding and Emma Wesley and Gareth Davies and George McFaul and Gill Watts and Guy Chung-Faye and Helen Clarke and Helen Dalal and Ian Gee and James Hart and Jimmy Limdi and Jo Taylor and John Beckly and John Fell and John Gordon and John Green and John Puntis and Jon Simmons and Jonathan Quinlan and Jonathan Snook and Kathleen Holding and Konstantinos Katsanos and Lucy Smyth and Malcolm Smith and Marcus Auth and Marcus Harbord and Marianne Mortimore and Mark Smith and Mark Thomas and Mark Tighe and Matthew Brookes and Melanie Lockett and Michael Delaney and Michael Schultz and Mundre Pradeep and Naomi Edney and Natalie Direkze and Neeraj Prasad and Neil Shah and Nick Croft and Paul Banim and Paul Dunckley and Pierre Ellul and Pradeep Bhandari and Pritash Patel and Rachel Cooney and Rakesh Chaudhary and Rebecca Saich and Renata D'Inca and Richard D'Souza and Richard Felwick and Pollok, {Richard P} and Richard Shenderay and Rosemary Phillips and Sandip Sen and Sean Weaver and Shaji Sebastian and Shani deSilva and Sheldon Cooper and Simon Campbell and Simon Everett and Simon Lal and Simon Panter and Sree Subramanian and Stefan Schreiber and Stephen Foley and Stephen Lewis and Steve Gore and Stuart Bloom and Subramaniam Ramakrishnan and Sue Cullen and Sunil Sonwalker and Suren Kanegasundaram and Tariq Iqbal and Tony Lopez and Vibeke Andersen and Zinu Philipose and Angus Watson and Chris Hawkey and Matt Nelson and Sally John and Jeffrey Waring and Scott Patterson and Bryan Barratt and Joe Walker and Peter Shaw and Steve Lewitzky and Michael Dunn and Tariq Ahmad",

year = "2014",

month = sep,

day = "26",

doi = "10.1038/ng.3093",

language = "English",

volume = "46",

pages = "1131--1134",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

Heap, G, Weedon, M, Bewshea, C, Singh, A, Chen, M, Satchwell, J, Vivian, J, So, K, Dubois, P, Andrews, J, Annese, V, Bampton, P, Barnardo, M, Bell, S, Cole, A, Connor, S, Creed, T, Cummings, F, D'Amato, M, Daneshmend, T, Fedorak, R, Florin, T, Gaya, D, Greig, E, Halfvarson, J, Hart, A, Irving, P, Jones, G, Karban, A, Lawrance, I, Lee, J, Lees, C, Lev-Tzion, R, Lindsay, J, Mansfield, J, Mawdsley, J, Mazhar, Z, Parkes, M, Parnell, K, Orchard, T, Radford-Smith, G, Russell, R, Reffitt, D, Satsangi, J, Silverberg, M, Sturniolo, G, Tremelling, M, Tsianos, E, van Heel, D, Walsh, A, Watermeyer, G, Weersma, R, Zeissig, S, Rossjohn, J, Holden, A, Shenoy, A, Dawood, A, Ireland, A, Lobo, A, Simmons, A, McNair, A, Franke, A, Bell, A, Milestone, A, Modi, A, Dhar, A, Willmott, A, Akobeng, A, Sharma, A, Hawthorne, B, Chaudhary, B, Edwards, C, Preston, C, Murray, C, Charlton, C, MacDonald, C, Jones, C, Mowat, C, Gavin, D, Campbell, D, Elphick, D, Grimes, D, Watts, D, Ghosh, D, Das, D, Vani, D, Spalding, E, Wesley, E, Davies, G, McFaul, G, Watts, G, Chung-Faye, G, Clarke, H, Dalal, H, Gee, I, Hart, J, Limdi, J, Taylor, J, Beckly, J, Fell, J, Gordon, J, Green, J, Puntis, J, Simmons, J, Quinlan, J, Snook, J, Holding, K, Katsanos, K, Smyth, L, Smith, M, Auth, M, Harbord, M, Mortimore, M, Smith, M, Thomas, M, Tighe, M, Brookes, M, Lockett, M, Delaney, M, Schultz, M, Pradeep, M, Edney, N, Direkze, N, Prasad, N, Shah, N, Croft, N, Banim, P, Dunckley, P, Ellul, P, Bhandari, P, Patel, P, Cooney, R, Chaudhary, R, Saich, R, D'Inca, R, D'Souza, R, Felwick, R, Pollok, RP, Shenderay, R, Phillips, R, Sen, S, Weaver, S, Sebastian, S, deSilva, S, Cooper, S, Campbell, S, Everett, S, Lal, S, Panter, S, Subramanian, S, Schreiber, S, Foley, S, Lewis, S, Gore, S, Bloom, S, Ramakrishnan, S, Cullen, S, Sonwalker, S, Kanegasundaram, S, Iqbal, T, Lopez, T, Andersen, V, Philipose, Z, Watson, A, Hawkey, C, Nelson, M, John, S, Waring, J, Patterson, S, Barratt, B, Walker, J, Shaw, P, Lewitzky, S, Dunn, M & Ahmad, T 2014, 'HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.', Nature Genetics, vol. 46, no. 10, pp. 1131-1134. https://doi.org/10.1038/ng.3093

TY - JOUR

T1 - HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

AU - Heap, Graham

AU - Weedon, Michael

AU - Bewshea, Claire

AU - Singh, Abhey

AU - Chen, Mian

AU - Satchwell, Jack

AU - Vivian, Julian

AU - So, Kenji

AU - Dubois, Patrick

AU - Andrews, Jane

AU - Annese, Vito

AU - Bampton, Peter

AU - Barnardo, Martin

AU - Bell, Sally

AU - Cole, Andy

AU - Connor, Susan

AU - Creed, Tom

AU - Cummings, Fraser

AU - D'Amato, Mauro

AU - Daneshmend, Tawfiqu

AU - Fedorak, Richard

AU - Florin, Timothy

AU - Gaya, Daniel

AU - Greig, Emma

AU - Halfvarson, Jonas

AU - Hart, Ailsa

AU - Irving, Peter

AU - Jones, Gareth

AU - Karban, Amir

AU - Lawrance, Ian

AU - Lee, James

AU - Lees, Charlie

AU - Lev-Tzion, Raffi

AU - Lindsay, James

AU - Mansfield, John

AU - Mawdsley, Joel

AU - Mazhar, Zia

AU - Parkes, Miles

AU - Parnell, Kirstie

AU - Orchard, Timothy

AU - Radford-Smith, Graham

AU - Russell, Richard

AU - Reffitt, David

AU - Satsangi, Jack

AU - Silverberg, Mark

AU - Sturniolo, Giacomo

AU - Tremelling, Mark

AU - Tsianos, Epameinondas

AU - van Heel, David

AU - Walsh, Alissa

AU - Watermeyer, Gill

AU - Weersma, Rinse

AU - Zeissig, Sebastian

AU - Rossjohn, Jamie

AU - Holden, Arthur

AU - Shenoy, Acuth

AU - Dawood, Ahmed

AU - Ireland, Alan

AU - Lobo, Alan

AU - Simmons, Alison

AU - McNair, Alistair

AU - Franke, Andre

AU - Bell, Andy

AU - Milestone, Andy

AU - Modi, Anita

AU - Dhar, Anjan

AU - Willmott, Anne

AU - Akobeng, Anthony

AU - Sharma, Asheesh

AU - Hawthorne, Barney

AU - Chaudhary, Basant

AU - Edwards, Cathryn

AU - Preston, Cathryn

AU - Murray, Charles

AU - Charlton, Charlie

AU - MacDonald, Chris

AU - Jones, Colin

AU - Mowat, Craig

AU - Gavin, Daniel

AU - Campbell, David

AU - Elphick, David

AU - Grimes, David

AU - Watts, David

AU - Ghosh, Deb

AU - Das, Debasish

AU - Vani, Deven

AU - Spalding, Elaine

AU - Wesley, Emma

AU - Davies, Gareth

AU - McFaul, George

AU - Watts, Gill

AU - Chung-Faye, Guy

AU - Clarke, Helen

AU - Dalal, Helen

AU - Gee, Ian

AU - Hart, James

AU - Limdi, Jimmy

AU - Taylor, Jo

AU - Beckly, John

AU - Fell, John

AU - Gordon, John

AU - Green, John

AU - Puntis, John

AU - Simmons, Jon

AU - Quinlan, Jonathan

AU - Snook, Jonathan

AU - Holding, Kathleen

AU - Katsanos, Konstantinos

AU - Smyth, Lucy

AU - Smith, Malcolm

AU - Auth, Marcus

AU - Harbord, Marcus

AU - Mortimore, Marianne

AU - Smith, Mark

AU - Thomas, Mark

AU - Tighe, Mark

AU - Brookes, Matthew

AU - Lockett, Melanie

AU - Delaney, Michael

AU - Schultz, Michael

AU - Pradeep, Mundre

AU - Edney, Naomi

AU - Direkze, Natalie

AU - Prasad, Neeraj

AU - Shah, Neil

AU - Croft, Nick

AU - Banim, Paul

AU - Dunckley, Paul

AU - Ellul, Pierre

AU - Bhandari, Pradeep

AU - Patel, Pritash

AU - Cooney, Rachel

AU - Chaudhary, Rakesh

AU - Saich, Rebecca

AU - D'Inca, Renata

AU - D'Souza, Richard

AU - Felwick, Richard

AU - Pollok, Richard P

AU - Shenderay, Richard

AU - Phillips, Rosemary

AU - Sen, Sandip

AU - Weaver, Sean

AU - Sebastian, Shaji

AU - deSilva, Shani

AU - Cooper, Sheldon

AU - Campbell, Simon

AU - Everett, Simon

AU - Lal, Simon

AU - Panter, Simon

AU - Subramanian, Sree

AU - Schreiber, Stefan

AU - Foley, Stephen

AU - Lewis, Stephen

AU - Gore, Steve

AU - Bloom, Stuart

AU - Ramakrishnan, Subramaniam

AU - Cullen, Sue

AU - Sonwalker, Sunil

AU - Kanegasundaram, Suren

AU - Iqbal, Tariq

AU - Lopez, Tony

AU - Andersen, Vibeke

AU - Philipose, Zinu

AU - Watson, Angus

AU - Hawkey, Chris

AU - Nelson, Matt

AU - John, Sally

AU - Waring, Jeffrey

AU - Patterson, Scott

AU - Barratt, Bryan

AU - Walker, Joe

AU - Shaw, Peter

AU - Lewitzky, Steve

AU - Dunn, Michael

AU - Ahmad, Tariq

PY - 2014/9/26

Y1 - 2014/9/26

N2 - Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 × 10 â '16). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the HLA region identified association with the HLA-DQA1∗02:01-HLA-DRB1∗07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.

AB - Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 × 10 â '16). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the HLA region identified association with the HLA-DQA1∗02:01-HLA-DRB1∗07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.

UR - http://www.scopus.com/inward/record.url?scp=84922070460&partnerID=8YFLogxK

U2 - 10.1038/ng.3093

DO - 10.1038/ng.3093

M3 - Article

SN - 1061-4036

VL - 46

SP - 1131

EP - 1134

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this