HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis

Sankar D. Navaneethan; Francesca Pansini; Vlado Perkovic; Carlo Manno; Fabio Pellegrini; David W. Johnson; Jonathan C. Craig; Giovanni F.M. Strippoli

doi:10.1002/14651858.CD007784

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis

Sankar D. Navaneethan, Francesca Pansini, Vlado Perkovic, Carlo Manno, Fabio Pellegrini, David W. Johnson, Jonathan C. Craig, Giovanni F.M. Strippoli

Flinders University

Research output: Contribution to journal › Review article › peer-review

171 Citations (Scopus)

Abstract

Patients with chronic kidney disease (CKD) are at very high risk of heart disease. Statins have been shown to decrease cholesterol levels and mortality in the general population. The aim of this review was to analyse if a similar effect could be shown in patients with non‐dialysis dependent CKD. This review identified 26 completed studies (25,017 patients). Statins decreased all‐cause mortality and cardiovascular mortality along with lowering lipid levels to an extent which is similar to that found in the general population. Statins also reduce protein excretion in urine but the impact of this on the risk of needing renal replacement therapy needs to be studied further. Statins were not found to have serious adverse effects in this group of people.

Original language	English
Article number	CD007784
Number of pages	54
Journal	Cochrane Database of Systematic Reviews
Issue number	2
DOIs	https://doi.org/10.1002/14651858.CD007784
Publication status	Published - 15 Apr 2009

Keywords

kidney disease
heart disease
Statins

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title = "HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis",

abstract = "Patients with chronic kidney disease (CKD) are at very high risk of heart disease. Statins have been shown to decrease cholesterol levels and mortality in the general population. The aim of this review was to analyse if a similar effect could be shown in patients with non‐dialysis dependent CKD. This review identified 26 completed studies (25,017 patients). Statins decreased all‐cause mortality and cardiovascular mortality along with lowering lipid levels to an extent which is similar to that found in the general population. Statins also reduce protein excretion in urine but the impact of this on the risk of needing renal replacement therapy needs to be studied further. Statins were not found to have serious adverse effects in this group of people.",

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HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. / Navaneethan, Sankar D.; Pansini, Francesca; Perkovic, Vlado; Manno, Carlo; Pellegrini, Fabio; Johnson, David W.; Craig, Jonathan C.; Strippoli, Giovanni F.M.

In: Cochrane Database of Systematic Reviews, No. 2, CD007784, 15.04.2009.

Research output: Contribution to journal › Review article › peer-review

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T1 - HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis

AU - Navaneethan, Sankar D.

AU - Pansini, Francesca

AU - Perkovic, Vlado

AU - Manno, Carlo

AU - Pellegrini, Fabio

AU - Johnson, David W.

AU - Craig, Jonathan C.

AU - Strippoli, Giovanni F.M.

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N2 - Patients with chronic kidney disease (CKD) are at very high risk of heart disease. Statins have been shown to decrease cholesterol levels and mortality in the general population. The aim of this review was to analyse if a similar effect could be shown in patients with non‐dialysis dependent CKD. This review identified 26 completed studies (25,017 patients). Statins decreased all‐cause mortality and cardiovascular mortality along with lowering lipid levels to an extent which is similar to that found in the general population. Statins also reduce protein excretion in urine but the impact of this on the risk of needing renal replacement therapy needs to be studied further. Statins were not found to have serious adverse effects in this group of people.

AB - Patients with chronic kidney disease (CKD) are at very high risk of heart disease. Statins have been shown to decrease cholesterol levels and mortality in the general population. The aim of this review was to analyse if a similar effect could be shown in patients with non‐dialysis dependent CKD. This review identified 26 completed studies (25,017 patients). Statins decreased all‐cause mortality and cardiovascular mortality along with lowering lipid levels to an extent which is similar to that found in the general population. Statins also reduce protein excretion in urine but the impact of this on the risk of needing renal replacement therapy needs to be studied further. Statins were not found to have serious adverse effects in this group of people.

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KW - heart disease

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