Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

Maria de Fátima Haueisen Sander Diniz, Alline Maria Rezende Beleigoli, Maria Inês Schmidt, Bruce B. Duncan, Antônio Luiz P. Ribeiro, Pedro G. Vidigal, Isabela M. Benseñor, Paulo A. Lotufo, Itamar S. Santos, Rosane H. Griep, Sandhi Maria Barreto

Research output: Contribution to journalArticlepeer-review

Abstract

Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories.

Original languageEnglish
Article numbere00072120
Number of pages7
JournalCadernos de Saude Publica
Volume36
Issue number8
DOIs
Publication statusPublished - 2 Sep 2020

Bibliographical note

This article is published in Open Access under the Creative Commons Attribution license, which allows use, distribution, and reproduction in any medium, without restrictions, as long as the original work is correctly cited

Keywords

  • Metabolic Syndrome
  • Insulin Resistance
  • Cohort Studies

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