Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations

Timothy J. Green, C. Murray Skeaff, Jennifer A. McMahon, Bernard J. Venn, Sheila M. Williams, Angela M. Devlin, Sheila M. Innis

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Elevated plasma total homocysteine (tHcy) is a risk factor for vascular disease but lowering tHcy with B-vitamins, including folate, has generally not reduced vascular events in secondary prevention trials. Elevated plasma S-adenosylhomocysteine (AdoHcy) concentration may be a more sensitive indicator of vascular disease than plasma tHcy. However, unlike tHcy, plasma AdoHcy did not correlate with folate concentration in one study indicating that folate supplementation may not lower AdoHcy. Our aim was to determine whether providing B-vitamin supplements to healthy older people with elevated tHcy (>13mol/l) affects plasma AdoHcy and S-adenosylmethionine (AdoMet) concentrations. Healthy older participants (n 276; ≥65 years) were randomised to receive a daily supplement containing folate (1mg), vitamin B12 (500μg) and vitamin B6 (10mg), or placebo, for 2 years. Of these participants, we selected the first fifty participants in each treatment group and measured plasma AdoHcy and AdoMet. Plasma tHcy was 44 (95% CI 32, 56; P<0001) mol/l lower at 2 years in the vitamins group compared with the placebo group. At 2 years, there were no significant differences in plasma AdoMet (+4% (95% CI 2, 11); P=019), AdoHcy (1% (95% CI 10, 8); P=061) or the AdoMet:AdoHcy ratio (022 (95% CI 004, 049); P=010) between the two groups. In conclusion, B-vitamin supplementation of older people lowered plasma tHcy but had no effect on plasma AdoMet or AdoHcy concentration. If elevated plasma AdoHcy is detrimental, this may explain why B-vitamins have generally failed to reduce vascular events in clinical trials.

Original languageEnglish
Pages (from-to)1629-1634
Number of pages6
JournalBritish Journal of Nutrition
Volume103
Issue number11
DOIs
Publication statusPublished - 14 Jun 2010
Externally publishedYes

Keywords

  • B vitamins
  • Clinical trials
  • Homocysteine
  • Older persons
  • S-Adenosylhomocysteine
  • S-Adenosylmethionine

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