How many patients do we need for a clinical trial? Demystifying sample size calculations

Patrick J. Kelly, Angela C. Webster, Jonathan C. Craig

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Determining the number of subjects required for a study is a critical component when planning a research project. An adequate number of patients are needed in order to be able to answer the research question of interest with a degree of certainty. In this paper, the information that is required for determining the sample size is described. The primary aim is to demystify the sample size section in published clinical trials. Some of the difficulties in determining the sample size correctly are also highlighted and some good practices recommended. Calculating the correct sample size can be challenging. This paper focuses on sample size calculations for hypothesis tests.

Original languageEnglish
Pages (from-to)725-731
Number of pages7
JournalNephrology
Volume15
Issue number8
DOIs
Publication statusPublished - 22 Dec 2010

Keywords

  • research methodologies
  • sample size
  • clinical trials
  • power
  • randomized controlled trial

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