HTLV-I and Strongyloides in Australia: The worm lurking beneath

Catherine A. Gordon, Jennifer M. Shield, Richard S. Bradbury, Stephen Muhi, Wendy Page, Jenni A. Judd, Rogan Lee, Beverley Ann Biggs, Kirstin Ross, Johanna Kurscheid, Darren J. Gray, Donald P. McManus

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Strongyloidiasis and HTLV-I (human T-lymphotropic virus-1) are important infections that are endemic in many countries around the world with an estimated 370 million infected with Strongyloides stercoralis alone, and 5–10 million with HTVL-I. Co-infections with these pathogens are associated with significant morbidity and can be fatal. HTLV-I infects T-cells thus causing dysregulation of the immune system which has been linked to dissemination and hyperinfection of S. stercoralis leading to bacterial sepsis which can result in death. Both of these pathogens are endemic in Australia primarily in remote communities in Queensland, the Northern Territory, and Western Australia. Other cases in Australia have occurred in immigrants and refugees, returned travellers, and Australian Defence Force personnel. HTLV-I infection is lifelong with no known cure. Strongyloidiasis is a long-term chronic disease that can remain latent for decades, as shown by infections diagnosed in prisoners of war from World War II and the Vietnam War testing positive decades after they returned from these conflicts. This review aims to shed light on concomitant infections of HTLV-I with S. stercoralis primarily in Australia but in the global context as well.

Original languageEnglish
Pages (from-to)119-201
Number of pages83
JournalAdvances in Parasitology
Volume111
DOIs
Publication statusPublished - 2021

Keywords

  • Australia
  • HTLV-1
  • HTLV-I
  • Human T-lymphotropic virus
  • Strongyloides fuelleborni fuelleborni
  • Strongyloides fuelleborni kellyi
  • Strongyloides stercoralis

Fingerprint

Dive into the research topics of 'HTLV-I and Strongyloides in Australia: The worm lurking beneath'. Together they form a unique fingerprint.

Cite this