Abstract
Sensory neurons with cell bodies situated in dorsal root ganglia convey information from external or internal sites of the body such as actual or potential harm, temperature or muscle length to the central nervous system. In recent years, large investigative efforts have worked toward an understanding of different types of DRG neurons at transcriptional, translational, and functional levels. These studies most commonly rely on data obtained from laboratory animals. Human DRG, however, have received far less investigative focus over the last 30 years. Nevertheless, knowledge about human sensory neurons is critical for a translational research approach and future therapeutic development. This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of human DRG neurons, in particular nociceptive neurons.
| Original language | English |
|---|---|
| Article number | 271 |
| Pages (from-to) | 271 |
| Number of pages | 5 |
| Journal | Frontiers in Cellular Neuroscience |
| Volume | 13 |
| DOIs | |
| Publication status | Published - 2019 |
Bibliographical note
Frontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.Keywords
- sensory neurons
- dorsal root ganglia
- trigeminal ganglia
- neurons
- anatomy
- Immunohistochemistry
- Nociceptor
- MRI
- DRG
- Satellite cells