Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.
|Number of pages||6|
|Journal||Mechanisms of Ageing and Development|
|Publication status||Published - May 1982|