Abstract
Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.
Original language | English |
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Pages (from-to) | 21-26 |
Number of pages | 6 |
Journal | Mechanisms of Ageing and Development |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 1982 |
Externally published | Yes |