Human lymphocytes resistant to 6-thioguanine increase with age

A. A. Morley, S. Cox, R. Holluday

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalMechanisms of Ageing and Development
Issue number1
Publication statusPublished - May 1982
Externally publishedYes


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