Human lymphocytes resistant to 6-thioguanine increase with age

A. A. Morley; S. Cox; R. Holluday

doi:10.1016/0047-6374(82)90046-X

Human lymphocytes resistant to 6-thioguanine increase with age

A. A. Morley
, S. Cox
, R. Holluday

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0047-6374(82)90046-X
Publication status	Published - May 1982
Externally published	Yes

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title = "Human lymphocytes resistant to 6-thioguanine increase with age",

abstract = "Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.",

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AU - Morley, A. A.

AU - Cox, S.

AU - Holluday, R.

PY - 1982/5

Y1 - 1982/5

N2 - Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.

AB - Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine-guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.

UR - https://www.scopus.com/pages/publications/0020459885

U2 - 10.1016/0047-6374(82)90046-X

DO - 10.1016/0047-6374(82)90046-X

M3 - Article

C2 - 7109703

AN - SCOPUS:0020459885

SN - 0047-6374

VL - 19

SP - 21

EP - 26

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 1

ER -

Human lymphocytes resistant to 6-thioguanine increase with age

Abstract

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