Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers

Luke A. Selth, Matthew J. Roberts, Clement W.K. Chow, Villis R. Marshall, Suhail A.R. Doi, Andrew D. Vincent, Lisa M. Butler, Martin F. Lavin, Wayne D. Tilley, Robert A. Gardiner

Research output: Contribution to journalLetter

25 Citations (Scopus)

Abstract

Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually performed following an elevated serum prostate-specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol & Carlsson 2013). While it is highly specific for tissues of prostatic origin, PSA is not cancer specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on PCa mortality (Schroder et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking.
Original languageEnglish
Pages (from-to)L17-L21
Number of pages5
JournalEndocrine-Related Cancer
Volume21
Issue number4
DOIs
Publication statusPublished - Aug 2014
Externally publishedYes

Keywords

  • Prostate cancer
  • microRNA
  • seminal fluid
  • biomarkers

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    Selth, L. A., Roberts, M. J., Chow, C. W. K., Marshall, V. R., Doi, S. A. R., Vincent, A. D., Butler, L. M., Lavin, M. F., Tilley, W. D., & Gardiner, R. A. (2014). Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers. Endocrine-Related Cancer, 21(4), L17-L21. https://doi.org/10.1530/ERC-14-0234