Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers

Luke A. Selth; Matthew J. Roberts; Clement W.K. Chow; Villis R. Marshall; Suhail A.R. Doi; Andrew D. Vincent; Lisa M. Butler; Martin F. Lavin; Wayne D. Tilley; Robert A. Gardiner

doi:10.1530/ERC-14-0234

Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers

Luke A. Selth, Matthew J. Roberts, Clement W.K. Chow, Villis R. Marshall, Suhail A.R. Doi, Andrew D. Vincent, Lisa M. Butler, Martin F. Lavin, Wayne D. Tilley, Robert A. Gardiner

Research output: Contribution to journal › Letter › peer-review

33 Citations (Scopus)

Abstract

Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually performed following an elevated serum prostate-specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol & Carlsson 2013). While it is highly specific for tissues of prostatic origin, PSA is not cancer specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on PCa mortality (Schroder et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking.

Original language	English
Pages (from-to)	L17-L21
Number of pages	5
Journal	Endocrine-Related Cancer
Volume	21
Issue number	4
DOIs	https://doi.org/10.1530/ERC-14-0234
Publication status	Published - Aug 2014
Externally published	Yes

Keywords

Prostate cancer
microRNA
seminal fluid
biomarkers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1530/ERC-14-0234Licence: In Copyright

Cite this

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title = "Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers",

abstract = "Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually performed following an elevated serum prostate-specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol & Carlsson 2013). While it is highly specific for tissues of prostatic origin, PSA is not cancer specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on PCa mortality (Schroder et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking.",

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T1 - Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers

AU - Selth, Luke A.

AU - Roberts, Matthew J.

AU - Chow, Clement W.K.

AU - Marshall, Villis R.

AU - Doi, Suhail A.R.

AU - Vincent, Andrew D.

AU - Butler, Lisa M.

AU - Lavin, Martin F.

AU - Tilley, Wayne D.

AU - Gardiner, Robert A.

PY - 2014/8

Y1 - 2014/8

N2 - Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually performed following an elevated serum prostate-specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol & Carlsson 2013). While it is highly specific for tissues of prostatic origin, PSA is not cancer specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on PCa mortality (Schroder et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking.

AB - Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually performed following an elevated serum prostate-specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol & Carlsson 2013). While it is highly specific for tissues of prostatic origin, PSA is not cancer specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on PCa mortality (Schroder et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking.

KW - Prostate cancer

KW - microRNA

KW - seminal fluid

KW - biomarkers

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SP - L17-L21

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JF - Endocrine-Related Cancer

IS - 4

ER -

Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers

Abstract

Keywords

UN SDGs

Access to Document

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