Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia

Kyle R. Crassini, Eva Zhang, Shalini Balendran, Jane A. Freeman, O. G. Best, Cecily J. Forsyth, Naomi J. Mackinlay, Ping Han, William S. Stevenson, Stephen P. Mulligan

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.
Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalBritish Journal of Haematology
Volume181
Issue number1
DOIs
Publication statusPublished - Apr 2018
Externally publishedYes

Keywords

  • Aged Disease-Free Survival Female Humans *IgG Deficiency/blood/immunology/mortality/therapy *Immunity, Humoral *Leukemia, Lymphocytic, Chronic, B-Cell/blood/immunology/mortality/therapy Male Middle Aged Survival Rate *chronic lymphocytic leukaemia *immunoglobulin *immunoglobulin G subclasses *survival
  • chronic lymphocytic leukaemia
  • immunoglobulin
  • survival
  • immunoglobulin G subclasses

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