Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.
- Aged Disease-Free Survival Female Humans *IgG Deficiency/blood/immunology/mortality/therapy *Immunity, Humoral *Leukemia, Lymphocytic, Chronic, B-Cell/blood/immunology/mortality/therapy Male Middle Aged Survival Rate *chronic lymphocytic leukaemia *immunoglobulin *immunoglobulin G subclasses *survival
- chronic lymphocytic leukaemia
- immunoglobulin G subclasses