Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia

Kyle R. Crassini; Eva Zhang; Shalini  Balendran; Jane A. Freeman; O. G. Best; Cecily J. Forsyth; Naomi J. Mackinlay; Ping Han; William S. Stevenson; Stephen P. Mulligan

doi:10.1111/bjh.15146

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia

Kyle R. Crassini, Eva Zhang, Shalini Balendran, Jane A. Freeman, O. G. Best, Cecily J. Forsyth, Naomi J. Mackinlay, Ping Han, William S. Stevenson, Stephen P. Mulligan

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	British Journal of Haematology
Volume	181
Issue number	1
DOIs	https://doi.org/10.1111/bjh.15146
Publication status	Published - Apr 2018
Externally published	Yes

Keywords

Aged Disease-Free Survival Female Humans *IgG Deficiency/blood/immunology/mortality/therapy *Immunity, Humoral *Leukemia, Lymphocytic, Chronic, B-Cell/blood/immunology/mortality/therapy Male Middle Aged Survival Rate *chronic lymphocytic leukaemia *immunoglobulin *immunoglobulin G subclasses *survival
chronic lymphocytic leukaemia
immunoglobulin
survival
immunoglobulin G subclasses

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Crassini, K. R., Zhang, E., Balendran, S., Freeman, J. A., Best, O. G., Forsyth, C. J., Mackinlay, N. J., Han, P., Stevenson, W. S., & Mulligan, S. P. (2018). Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia. British Journal of Haematology, 181(1), 97-101. https://doi.org/10.1111/bjh.15146

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title = "Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia",

abstract = "Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.",

keywords = "Aged Disease-Free Survival Female Humans *IgG Deficiency/blood/immunology/mortality/therapy *Immunity, Humoral *Leukemia, Lymphocytic, Chronic, B-Cell/blood/immunology/mortality/therapy Male Middle Aged Survival Rate *chronic lymphocytic leukaemia *immunoglobulin *immunoglobulin G subclasses *survival, chronic lymphocytic leukaemia, immunoglobulin, survival, immunoglobulin G subclasses",

author = "Crassini, {Kyle R.} and Eva Zhang and Shalini Balendran and Freeman, {Jane A.} and Best, {O. G.} and Forsyth, {Cecily J.} and Mackinlay, {Naomi J.} and Ping Han and Stevenson, {William S.} and Mulligan, {Stephen P.}",

year = "2018",

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Crassini, KR, Zhang, E, Balendran, S, Freeman, JA, Best, OG, Forsyth, CJ, Mackinlay, NJ, Han, P, Stevenson, WS & Mulligan, SP 2018, 'Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia', British Journal of Haematology, vol. 181, no. 1, pp. 97-101. https://doi.org/10.1111/bjh.15146

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia. / Crassini, Kyle R.; Zhang, Eva; Balendran, Shalini et al.
In: British Journal of Haematology, Vol. 181, No. 1, 04.2018, p. 97-101.

Research output: Contribution to journal › Article › peer-review

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AU - Zhang, Eva

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AU - Forsyth, Cecily J.

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Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia

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