Hyaluronic acid for post sinus surgery care: Systematic review and meta-analysis

E Fong, M Garcia, CM Woods, E Ooi

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Background: Wound healing after endoscopic sinus surgery may result in adhesion formation. Hyaluronic acid may prevent synechiae development. A systematic review was performed to evaluate the current evidence on the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery.

Methods: Studies using hyaluronic acid as an adjunct treatment following endoscopic sinus surgery for chronic rhinosinusitis were identified. The primary outcome was adhesion formation rates. A meta-analysis was performed on adhesion event frequency. Secondary outcome measures included other endoscopic findings and patient reported outcomes.

Results: Thirteen studies (501 patients) met the selection criteria. A meta-analysis of adhesion formation frequency on endoscopy demonstrated a lower risk ratio in the hyaluronic acid intervention group (42 out of 283 cases) compared to the control group (81 out of 282) of 0.52 (95 per cent confidence interval = 0.37–0.72). Hyaluronic acid use was not associated with any significant adverse events.

Conclusion: Hyaluronic acid appears to be clinically safe and well tolerated, and may be useful in the early stages after sinus surgery to limit adhesion rate. Further research, including larger randomised controlled trials, is required to evaluate patient- and clinician-reported outcomes of hyaluronic acid post sinus surgery.
Original languageEnglish
Pages (from-to)S2-S11
Number of pages10
JournalJournal of Laryngology and Otology
Issue numberS1
Publication statusPublished - 2017


  • Rhinitis
  • Surgery
  • Quality of Life
  • Drug therapy
  • Hyaluronic Acid


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