Hydrothermal Synthesis of Monodispersed BaGdF5:Yb/Er Nanoparticles for CT and MR Imaging

Rongjin Sun, Ting Yin, Peng Huang, Guo Gao, Joseph Shapter, Yulan Shen, Jingjing Zhang, Daxiang Cui

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In this paper, we report the development of a facile one-pot hydrothermal method for the controlled synthesis of monodispersed BaGdF5 :Yb/Er nanoparticles for computed tomography (CT) and magnetic resonance (MR) imaging. The as-prepared nanoparticles have uniform size with a diameter of 20–25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/mL, suggesting that the as-prepared BaGdF5 :Yb/Er nanoparticles possess low toxicity. For both BaGdF5 :Yb/Er nanoparticles and iopromide, the Hounsfield unit (HU) values increase with the their concentration. The slope of BaGdF5 :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF5 :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF5 :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging.

Original languageEnglish
Pages (from-to)977-984
Number of pages8
Issue number12
Publication statusPublished - 1 Dec 2016


  • Computed tomography
  • Hydrothermal
  • Magnetic resonance
  • Nanoparticles
  • Upconversion


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