Hypertensive disorders of pregnancy and later cardiovascular disease risk in mothers and children

Michelle D. Plummer, Prabha H. Andraweer, Amy Garrett, Shalem Leemaqz, Melanie Wittwer, Emily Aldridge, Margaret A. Arstal, Gustaaf A. Dekker, Claire T. Robert

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Preeclampsia (PE) and gestational hypertension (GH) are pregnancy-specific diseases that occur in around 10% of pregnancies worldwide. Increasing evidence suggests that women whose pregnancies were complicated by PE or GH, and their offspring, are at increased risk of cardiovascular disease (CVD) later in life. We hypothesised that PE and GH would associate with CVD risk factors 8-10 years after the first pregnancy in the mother and child and that differences in cardiovascular risk profile would be seen between 8- and 10-year-old male and female children. This is a follow-up study of the Adelaide SCOPE pregnancy cohort where 1164 nulliparous women and their babies were recruited between 2005 and 2008. Haemodynamic function was assessed using non-invasive USCOMBP+ and USCOM1A devices. Microvascular function was assessed by post-occlusive reactive hyperaemia. Of the 273 mother-child pairs followed up, 38 women had PE and 20 had GH during pregnancy. Augmentation index (Aix) and suprasystolic pulse pressure (ssPP) were increased, whereas measures of microvascular function were decreased in children who were born to PE compared to uncomplicated pregnancies. Female children had decreased Aix and ssPP compared to male children after in utero exposure to PE. Women who developed GH during their first pregnancy had increased systolic, diastolic and mean arterial pressures compared to women who had uncomplicated pregnancy. Our data suggest thatGHis associated with increased cardiovascular risk in women 8-10 years after first pregnancy and PE is associated with increased offspring risk at 8-10 years of age, highlighting differences between these two hypertensive disorders of pregnancy.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalJournal of Developmental Origins of Health and Disease
Issue number4
Early online date15 Oct 2020
Publication statusPublished - Aug 2021


  • Cardiovascular risk
  • Children
  • Hypertensive disorders of pregnancy
  • Mothers
  • Sexual dimorphism
  • mothers
  • children
  • cardiovascular risk
  • sexual dimorphism


Dive into the research topics of 'Hypertensive disorders of pregnancy and later cardiovascular disease risk in mothers and children'. Together they form a unique fingerprint.

Cite this