Identifcation of clonal cells by repeats in (eg.) T-cell receptor V/D/J genes.

Alexander Morley (Inventor), Michael Brisco (Inventor), Pamela Sykes (Inventor)

    Research output: Patent

    Abstract

    The present invention relates to a method of characterising a marker nucleic acid region which is a rearranged immunoglobulin or T cell receptor variable region gene. The method of the present invention is based on identification of one or both of the nucleic acid regions flanking said marker nucleic acid region and provides a means of analysing said marker nucleic acid region which is characteristic of a clonal population of cells. The method of the present invention is useful in the context of enabling a range of applications including, but not limited to, monitoring the progression of a condition characterised by the presence of a clonal populations of cells (such as a neoplastic condition), monitoring the levels of one or more clonal cell population, predicting the likelihood of a subject's relapse from a remissive state to a disease state, for assessing the effectiveness of existing therapeutic drugs and/or new therapeutic agents.
    Original languageEnglish
    Patent numberEP1633884B1
    IPCC12Q1/68
    Priority date13/05/03
    Publication statusPublished - 2004

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