Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine

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    Abstract

    Myenteric neurons which innervate the mucosa of the guinea-pig ileum were characterized by combining retrograde transport of DiI in vitro with immunohistochemistry. Of DiI-labelled myenteric neurons, 43% were immunoreactive for calbindin and substance P, 25% were immunoreactive for calbindin alone, and 18% were immunoreactive for substance P alone. These 3 classes of neurons had Dogiel Type II morphology and are probably sensory neurons. Two classes of probable secretomotor neurons were characterized by immunoreactivity for neuropeptide Y (4%) and vasoactive intestinal peptide (2%). These 5 classes of myenteric neurons represent over 90% of the retrogradely labelled myenteric neurons that project to the mucosa.

    Original languageEnglish
    Pages (from-to)294-298
    Number of pages5
    JournalNeuroscience letters
    Volume129
    Issue number2
    DOIs
    Publication statusPublished - 19 Aug 1991

    Keywords

    • DiI
    • Enteric
    • Immunohistochemistry
    • Intestine
    • Mucosa
    • Myenteric plexus
    • Retrograde transport

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