Identification of ruxolitinib resistant mutations in Pro-B cells driven by a high-risk B-ALL JAK2 Fusion

Charlotte EJ Downes; Barbara J McClure; Benjamin Mayne; John B Bruning; Susan L Heatley; Timothy P Hughes; David T Yeung; Deborah L White

Identification of ruxolitinib resistant mutations in Pro-B cells driven by a high-risk B-ALL JAK2 Fusion

Charlotte EJ Downes
, Barbara J McClure
, Benjamin Mayne
, John B Bruning
, Susan L Heatley
, Timothy P Hughes
, David T Yeung
, Deborah L White

Research output: Contribution to conference › Poster

Abstract

We modelled and characterised rux resistance in JAK2r B-ALL in vitro to enable development of therapeutic strategies to overcome or avert resistance in these high-risk patients.

Original language	English
Number of pages	1
Publication status	Published - 30 May 2018
Externally published	Yes
Event	Adelaide Protein Group Student Awards 2018 - Adelaide, Australia Duration: 30 May 2018 → …

Conference

Conference	Adelaide Protein Group Student Awards 2018
Abbreviated title	APG Student Awards 2018
Country/Territory	Australia
City	Adelaide
Period	30/05/18 → …

Keywords

Ruxolitinib
Mutation
Pro-B Cells
B-ALL JAK2-fusion

Precision medicine approaches for JAK2-rearranged ALL: The efficacy of targeted therapies and molecular mechanisms of drug resistance
Toomes, C. (Associate Investigator), White, D. L. (Chief Investigator (Project Lead)), McClure, B. (Associate Investigator) & Bruning, J. B. (Associate Investigator)
12/03/18 → 31/12/22
Project: Research

Cite this

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title = "Identification of ruxolitinib resistant mutations in Pro-B cells driven by a high-risk B-ALL JAK2 Fusion",

abstract = "We modelled and characterised rux resistance in JAK2r B-ALL in vitro to enable development of therapeutic strategies to overcome or avert resistance in these high-risk patients.",

keywords = "Ruxolitinib, Mutation, Pro-B Cells, B-ALL JAK2-fusion",

author = "Downes, \{Charlotte EJ\} and McClure, \{Barbara J\} and Benjamin Mayne and Bruning, \{John B\} and Heatley, \{Susan L\} and Hughes, \{Timothy P\} and Yeung, \{David T\} and White, \{Deborah L\}",

year = "2018",

month = may,

day = "30",

language = "English",

note = "Adelaide Protein Group Student Awards 2018, APG Student Awards 2018 ; Conference date: 30-05-2018",

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TY - CONF

T1 - Identification of ruxolitinib resistant mutations in Pro-B cells driven by a high-risk B-ALL JAK2 Fusion

AU - Downes, Charlotte EJ

AU - McClure, Barbara J

AU - Mayne, Benjamin

AU - Bruning, John B

AU - Heatley, Susan L

AU - Hughes, Timothy P

AU - Yeung, David T

AU - White, Deborah L

PY - 2018/5/30

Y1 - 2018/5/30

N2 - We modelled and characterised rux resistance in JAK2r B-ALL in vitro to enable development of therapeutic strategies to overcome or avert resistance in these high-risk patients.

AB - We modelled and characterised rux resistance in JAK2r B-ALL in vitro to enable development of therapeutic strategies to overcome or avert resistance in these high-risk patients.

KW - Ruxolitinib

KW - Mutation

KW - Pro-B Cells

KW - B-ALL JAK2-fusion

M3 - Poster

T2 - Adelaide Protein Group Student Awards 2018

Y2 - 30 May 2018

ER -

Identification of ruxolitinib resistant mutations in Pro-B cells driven by a high-risk B-ALL JAK2 Fusion

Abstract

Conference

Keywords

Fingerprint

Projects

Precision medicine approaches for JAK2-rearranged ALL: The efficacy of targeted therapies and molecular mechanisms of drug resistance

Cite this