Sphingosine 1-phosphate (S1P) is generated from the phosphorylation of sphingosine by sphingosine kinase 1 (SPHK1) or sphingosine kinase 2 (SPHK2) (Pyne et al, 2016). Overexpression of SPHK1 has indisputable tumour-promotingproperties (Pyne & Pyne, 2010) and is associated with imatinib resistance in chronic myeloid leukaemia (Bonhoure et al, 2008; Marfe et al, 2011) and daunorubicin and cytarabine resistance in acute myeloid leukaemia cells (Sobue et al, 2008; Powell et al, 2017). We recently reported the involvement of SPHK2 in acute lymphoblastic leukaemia (ALL) (Wallington-Beddoe et al, 2014) and here we describe a rolefor SPHK1.
- novel therapies
- sphingosine kinase