Identification, Review, and Use of Health State Utilities in Cost-Effectiveness Models: An ISPOR Good Practices for Outcomes Research Task Force Report

John Brazier, Roberta Ara, Ismail Azzabi, Jan Busschbach, Hélène Chevrou-Séverac, Bruce Crawford, Luciane Cruz, John Karnon, Andrew Lloyd, Suzy Paisley, A. Simon Pickard

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cost-effectiveness models that present results in terms of cost per quality-adjusted life-year for health technologies are used to inform policy decisions in many parts of the world. Health state utilities (HSUs) are required to calculate the quality-adjusted life-years. Even when clinical studies assessing the effectiveness of health technologies collect data on HSUs to populate a cost-effectiveness model, which rarely happens, analysts typically need to identify at least some additional HSUs from alternative sources. When possible, HSUs are identified by a systematic review of the literature, but, again, this rarely happens. In 2014, ISPOR established a Good Practices for Outcome Research Task Force to address the use of HSUs in cost-effectiveness models. This task force report provides recommendations for researchers who identify, review, and synthesize HSUs for use in cost-effectiveness models; analysts who use the results in models; and reviewers who critically appraise the suitability and validity of the HSUs selected for use in models. The associated Minimum Reporting Standards of Systematic Review of Utilities for Cost-Effectiveness checklist created by the task force provides criteria to judge the appropriateness of the HSUs selected for use in cost-effectiveness models and is suitable for use in different international settings.

Original languageEnglish
Pages (from-to)267-275
Number of pages9
JournalValue in Health
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019
Externally publishedYes

Keywords

  • cost effectiveness
  • economic evaluation
  • health state utility
  • preference-based
  • quality of life
  • systematic reviews
  • utilities

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