@article{19f416f123ce4e7cb2e7fd498b198788,
title = "Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database",
abstract = "Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013.",
keywords = "Acute hypoxemic respiratory failure, Acute respiratory distress syndrome, Diabetes mellitus, LUNG SAFE",
author = "Boyle, {Andrew J.} and Fabiana Madotto and Laffey, {John G.} and Giacomo Bellani and T{\`a}i Pham and Antonio Pesenti and Thompson, {B. Taylor} and O'Kane, {Cecilia M.} and Deane, {Adam M.} and McAuley, {Daniel F.} and {LUNG SAFE Investigators} and {ESICM Trials Group} and F. Rios and {Van Haren}, F. and Faruq, {M. O.} and T. Sottiaux and P. Depuydt and Lora, {F. S.} and Azevedo, {L. C.} and E. Fan and G. Bugedo and H. Qiu and M. Gonzalez and J. Silesky and V. Cerny and J. Nielsen and M. Jibaja and H. Wrigge and D. Matamis and Ranero, {J. L.} and C. Gomersall and P. Amin and Hashemian, {S. M.} and K. Clarkson and K. Kurahashi and Y. Koh and A. Villagomez and Zeggwagh, {A. A.} and Heunks, {L. M.} and Laake, {J. H.} and W. Kashif and J. Synclair and Palo, {J. E.} and {do Vale Fernandes}, A. and D. Sandesc and Y. Arabi and V. Bumbasierevic and N. Nin and Lorente, {J. A.} and A. Larsson and L. Piquilloud and B. Patjanasoontorn and F. Abroug and L. McNamee and J. Hurtado and E. Bajwa and G. D{\'e}mpaire and Francois, {G. M.} and F. Rabboni and S. Conti and H. Sula and Lordian Nunci and A. Cani and A. Zazu and C. Dellera and Insaurralde, {C. S.} and Alejandro, {R. V.} and J. Daldin and Mauricio Vinzio and Fernandez, {R. O.} and Cardonnet, {L. P.} and Bettini, {L. R.} and Bisso, {M. C.} and Osman, {E. M.} and Setten, {M. G.} and P. Lovazzano and J. Alvarez and V. Villar and Pozo, {N. C.} and N. Grubissich and Plotnikow, {G. A.} and Vasquez, {D. N.} and S. Ilutovich and N. Tiribelli and A. Chena and Pellegrini, {C. A.} and Saenz, {M. G.} and E. Estenssoro and M. Brizuela and H. Gianinetto and Gomez, {P. E.} and Cerrato, {V. I.} and Bezzi, {M. G.} and Borello, {S. A.} and Loiacono, {F. A.} and Fernandez, {A. M.} and S. Knowles and C. Reynolds and Inskip, {D. M.} and Miller, {J. J.} and J. Kong and C. Whitehead and S. Bihari and A. Seven and A. Krstevski and Rodgers, {H. J.} and Millar, {R. T.} and Mckenna, {T. E.} and Bailey, {I. M.} and Hanlon, {G. C.} and A. Aneman and Lynch, {J. M.} and R. Azad and J. Neal and Woods, {P. W.} and Roberts, {B. L.} and Kol, {M. R.} and Wong, {H. S.} and Riss, {K. C.} and T. Staudinger and X. Wittebole and C. Berghe and Bulpa, {P. A.} and Dive, {A. M.} and R. Verstraete and H. Lebbinck and P. Depuydt and J. Vermassen and Philippe Meersseman and H. Ceunen and Rosa, {J. I.} and Beraldo, {D. O.} and C. Piras and Rampinelli, {A. M.} and Nassar, {A. P.} and S. Mataloun and M. Moock and Thompson, {M. M.} and Gon{\c c}alves, {C. H.} and ACP Ant{\^o}nio and A. Ascoli and Biondi, {R. S.} and Fontenele, {D. C.} and D. Nobrega and Sales, {V. M.} and S. Shindhe and {Pg Hj Ismail}, DMAB and F. Beloncle and Davies, {K. G.} and R. Cirone and V. Manoharan and M. Ismail and Goligher, {E. C.} and M. Jassal and Ferguson, {N. D.} and E. Nishikawa and A. Javeed and G. Curley and N. Rittayamai and M. Parotto and S. Mehta and J. Knoll and A. Pronovost and S. Canestrini and SCAR Bruhn and Garcia, {P. H.} and Aliaga, {F. A.} and Far{\'i}as, {P. A.} and Yumha, {J. S.} and Ortiz, {C. A.} and Salas, {J. E.} and Saez, {A. A.} and Vega, {L. D.} and Labarca, {E. F.} and Martinez, {F. T.} and Carre{\~n}o, {N. G.} and P. Lora and H. Liu and Haibo Qiu and L. Liu and R. Tang and X. Luo and Y. An and H. Zhao and Y. Gao and Z. Zhai and Ye, {Z. L.} and W. Wang and W. Li and Q. Li and R. Zheng and W. Yu and J. Shen and X. Li and T. Yu and W. Lu and Wu, {Y. Q.} and Huang, {X. B.} and Z. He and Y. Lu and H. Han and F. Zhang and R. Sun and Wang, {H. X.} and Qin, {S. H.} and Zhu, {B. H.} and J. Zhao and J. Liu and B. Li and Liu, {J. L.} and Zhou, {F. C.} and Li, {Q. J.} and Zhang, {X. Y.} and Z. Li-Xin and Q. Xin-Hua and L. Jiang and Gao, {Y. N.} and Zhao, {X. Y.} and Y. Li and Li, {X. L.} and C. Wang and Q. Yao and R. Yu and K. Chen and H. Shao and B. Qin and Huang, {Q. Q.} and Zhu, {W. H.} and Hang, {A. Y.} and Hua, {M. X.} and Y. Li and Y. Xu and Di, {Y. D.} and Ling, {L. L.} and Qin, {T. H.} and Wang, {S. H.} and J. Qin and Y. Han and S. Zhou and Vargas, {M. P.} and {Silesky Jimenez}, {J. I.} and {Gonz{\'a}lez Rojas}, {M. A.} and Solis-Quesada, {J. E.} and Ramirez-Alfaro, {C. M.} and J. M{\'a}ca and P. Sklienka and J. Gjedsted and A. Christiansen and Jonas Nielsen and Villamagua, {B. G.} and M. Llano and P. Burtin and G. Buzancais and P. Beuret and N. Pelletier and S. Mortaza and A. Mercat and J. Chelly and S. Jochmans",
note = "This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated",
year = "2018",
month = oct,
day = "27",
doi = "10.1186/s13054-018-2158-y",
language = "English",
volume = "22",
journal = "Critical Care",
issn = "1364-8535",
publisher = "BioMed Central Ltd.",
number = "1",
}
