IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation

Lih En Hong; Mihir D. Wechalekar; Monika Kutyna; Annabelle Small; Kelly Lim; Chloe Thompson-Peach; Joule J. Li; Rakchha Chhetri; Hamish S. Scott; Anna Brown; Christopher N. Hahn; David T. Yeung; Salvia Sajid; Nirmal Robinson; Ranjeny Thomas; Susan Branford; Richard J. D'Andrea; Saumya E. Samaraweera; Mrinal Patnaik; Susanna Proudman; Daniel Thomas; Chung Hoow Kok; Mithun V. Shah; Devendra K. Hiwase

doi:10.1182/blood.2023023593

IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation

Lih En Hong
, Mihir D. Wechalekar
, Monika Kutyna
, Annabelle Small
, Kelly Lim
, Chloe Thompson-Peach
, Joule J. Li
, Rakchha Chhetri
, Hamish S. Scott
, Anna Brown
, Christopher N. Hahn
, David T. Yeung
, Salvia Sajid
, Nirmal Robinson
, Ranjeny Thomas
, Susan Branford
, Richard J. D'Andrea
, Saumya E. Samaraweera
, Mrinal Patnaik
, Susanna Proudman

Daniel Thomas, Chung Hoow Kok, Mithun V. Shah, Devendra K. Hiwase

College of Medicine and Public Health

Research output: Contribution to journal › Letter › peer-review

16 Citations (Scopus)

67 Downloads (Pure)

Abstract

High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.

Original language	English
Pages (from-to)	1873-1877
Number of pages	5
Journal	Blood
Volume	143
Issue number	18
DOIs	https://doi.org/10.1182/blood.2023023593
Publication status	Published - 2 May 2024

Bibliographical note

Publisher Copyright:
© 2024 American Society of Hematology

Keywords

MDS
AIRD
t-MN
autoimmune rheumatic diseases

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10.1182/blood.2023023593Licence: CC BY-NC-ND

Final published versionFinal published version, 820 KBLicence: CC BY-NC-ND

Cite this

Hong, L. E., Wechalekar, M. D., Kutyna, M., Small, A., Lim, K., Thompson-Peach, C., Li, J. J., Chhetri, R., Scott, H. S., Brown, A., Hahn, C. N., Yeung, D. T., Sajid, S., Robinson, N., Thomas, R., Branford, S., D'Andrea, R. J., Samaraweera, S. E., Patnaik, M., ... Hiwase, D. K. (2024). IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation. Blood, 143(18), 1873-1877. https://doi.org/10.1182/blood.2023023593

@article{a517ba24c2434e22808482067382dd1f,

title = "IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation",

abstract = "High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.",

keywords = "MDS, AIRD, t-MN, autoimmune rheumatic diseases",

author = "Hong, \{Lih En\} and Wechalekar, \{Mihir D.\} and Monika Kutyna and Annabelle Small and Kelly Lim and Chloe Thompson-Peach and Li, \{Joule J.\} and Rakchha Chhetri and Scott, \{Hamish S.\} and Anna Brown and Hahn, \{Christopher N.\} and Yeung, \{David T.\} and Salvia Sajid and Nirmal Robinson and Ranjeny Thomas and Susan Branford and D'Andrea, \{Richard J.\} and Samaraweera, \{Saumya E.\} and Mrinal Patnaik and Susanna Proudman and Daniel Thomas and Kok, \{Chung Hoow\} and Shah, \{Mithun V.\} and Hiwase, \{Devendra K.\}",

note = "Publisher Copyright: {\textcopyright} 2024 American Society of Hematology",

year = "2024",

month = may,

day = "2",

doi = "10.1182/blood.2023023593",

language = "English",

volume = "143",

pages = "1873--1877",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

number = "18",

}

Hong, LE, Wechalekar, MD, Kutyna, M, Small, A, Lim, K, Thompson-Peach, C, Li, JJ, Chhetri, R, Scott, HS, Brown, A, Hahn, CN, Yeung, DT, Sajid, S, Robinson, N, Thomas, R, Branford, S, D'Andrea, RJ, Samaraweera, SE, Patnaik, M, Proudman, S, Thomas, D, Kok, CH, Shah, MV & Hiwase, DK 2024, 'IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation', Blood, vol. 143, no. 18, pp. 1873-1877. https://doi.org/10.1182/blood.2023023593

TY - JOUR

T1 - IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation

AU - Hong, Lih En

AU - Wechalekar, Mihir D.

AU - Kutyna, Monika

AU - Small, Annabelle

AU - Lim, Kelly

AU - Thompson-Peach, Chloe

AU - Li, Joule J.

AU - Chhetri, Rakchha

AU - Scott, Hamish S.

AU - Brown, Anna

AU - Hahn, Christopher N.

AU - Yeung, David T.

AU - Sajid, Salvia

AU - Robinson, Nirmal

AU - Thomas, Ranjeny

AU - Branford, Susan

AU - D'Andrea, Richard J.

AU - Samaraweera, Saumya E.

AU - Patnaik, Mrinal

AU - Proudman, Susanna

AU - Thomas, Daniel

AU - Kok, Chung Hoow

AU - Shah, Mithun V.

AU - Hiwase, Devendra K.

PY - 2024/5/2

Y1 - 2024/5/2

N2 - High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.

AB - High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.

KW - MDS

KW - AIRD

KW - t-MN

KW - autoimmune rheumatic diseases

UR - https://www.scopus.com/pages/publications/85188022438

U2 - 10.1182/blood.2023023593

DO - 10.1182/blood.2023023593

M3 - Letter

C2 - 38457663

AN - SCOPUS:85188022438

SN - 0006-4971

VL - 143

SP - 1873

EP - 1877

JO - Blood

JF - Blood

IS - 18

ER -

IDH-Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation

Abstract

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Keywords

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