IgG antibodies to Aspergillus fumigatus in cystic fibrosis: a laboratory correlate of disease activity

K D Forsyth, A W Hohmann, A J Martin, J Bradley

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    Abstract

    Serum was collected from 50 patients with cystic fibrosis, and IgG antibodies to Aspergillus fumigatus were measured by enzyme linked immunosorbent assay (ELISA). In addition, total IgE and Aspergillus specific IgE antibodies were measured in 41 of the 50. A close association was found between pulmonary function and clinical state, and IgG antibodies to Aspergillus. There was no association between pulmonary function or clinical state and IgE antibodies. It is postulated that in patients with cystic fibrosis, Aspergillus fumigatus may contribute to deterioration in pulmonary function by local pathogenicity, or by hypersensitivity mechanisms mediated by IgG.

    Original languageEnglish
    Pages (from-to)953-957
    Number of pages5
    JournalArchives of Disease in Childhood
    Volume63
    Issue number8
    DOIs
    Publication statusPublished - Aug 1988

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