TY - JOUR
T1 - IgG antibodies to Aspergillus fumigatus in cystic fibrosis
T2 - a laboratory correlate of disease activity
AU - Forsyth, K D
AU - Hohmann, A W
AU - Martin, A J
AU - Bradley, J
PY - 1988/8
Y1 - 1988/8
N2 - Serum was collected from 50 patients with cystic fibrosis, and IgG antibodies to Aspergillus fumigatus were measured by enzyme linked immunosorbent assay (ELISA). In addition, total IgE and Aspergillus specific IgE antibodies were measured in 41 of the 50. A close association was found between pulmonary function and clinical state, and IgG antibodies to Aspergillus. There was no association between pulmonary function or clinical state and IgE antibodies. It is postulated that in patients with cystic fibrosis, Aspergillus fumigatus may contribute to deterioration in pulmonary function by local pathogenicity, or by hypersensitivity mechanisms mediated by IgG.
AB - Serum was collected from 50 patients with cystic fibrosis, and IgG antibodies to Aspergillus fumigatus were measured by enzyme linked immunosorbent assay (ELISA). In addition, total IgE and Aspergillus specific IgE antibodies were measured in 41 of the 50. A close association was found between pulmonary function and clinical state, and IgG antibodies to Aspergillus. There was no association between pulmonary function or clinical state and IgE antibodies. It is postulated that in patients with cystic fibrosis, Aspergillus fumigatus may contribute to deterioration in pulmonary function by local pathogenicity, or by hypersensitivity mechanisms mediated by IgG.
UR - http://www.scopus.com/inward/record.url?scp=0023713344&partnerID=8YFLogxK
U2 - 10.1136/adc.63.8.953
DO - 10.1136/adc.63.8.953
M3 - Article
C2 - 3046514
AN - SCOPUS:0023713344
SN - 0003-9888
VL - 63
SP - 953
EP - 957
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
IS - 8
ER -