TY - JOUR
T1 - ‘IHPBA-APHPBA clinical practice guidelines’
T2 - international Delphi consensus recommendations for gallbladder cancer
AU - IHPBA-APHPBA International Study Group of Gallbladder Cancer
AU - Palepu, Jagannath
AU - Endo, Itaru
AU - Chaudhari, Vikram Anil
AU - Murthy, G. V.S.
AU - Chaudhuri, Sirshendu
AU - Adam, Rene
AU - Smith, Martin
AU - de Reuver, Philip R.
AU - Lendoire, Javier
AU - Shrikhande, Shailesh V.
AU - De Aretxabala, Xabier
AU - Sirohi, Bhawna
AU - Kokudo, Norihiro
AU - Kwon, Wooil
AU - Pal, Sujoy
AU - Bouzid, Chafik
AU - Dixon, Elijah
AU - Shah, Sudeep Rohit
AU - Maroni, Rodrigo
AU - Nervi, Bruno
AU - Mengoa, Claudio
AU - Patil, Shekhar
AU - Ebata, Tomoki
AU - Maithel, Shishir K.
AU - Lang, Hauke
AU - Primrose, John
AU - Hirano, Satoshi
AU - Guevara, Oscar A.
AU - Ohtsuka, Masayuki
AU - Valle, Juan W.
AU - Sharma, Atul
AU - Nagarajan, Ganesh
AU - Núñez Ju, Juan Jose
AU - Arroyo, Gerardo Francisco
AU - Torrez, Sergio Lopez
AU - Erdmann, Joris Ivo
AU - Butte, Jean M.
AU - Furuse, Junji
AU - Lee, Seung Eun
AU - Gomes, António Pedro
AU - Park, Sang Jae
AU - Jang, Jin Young
AU - Oddi, Ricardo
AU - Barreto, Savio George
AU - Kijima, Hiroshi
AU - Ciacio, Oriana
AU - Gowda, Nagesh S.
AU - Jarnagin, William
PY - 2024/11
Y1 - 2024/11
N2 - Background: The Delphi consensus study was carried out under the auspices of the International and Asia-Pacific Hepato-Pancreato-Biliary Associations (IHPBA-APHPBA) to develop practice guidelines for management of gallbladder cancer (GBC) globally. Method: GBC experts from 17 countries, spanning 6 continents, participated in a hybrid four-round Delphi consensus development process. The methodology involved email, online consultations, and in-person discussions. Sixty eight clinical questions (CQs) covering various domains related to GBC, were administered to the experts. A consensus recommendation was accepted only when endorsed by more than 75% of the participating experts. Results: Out of the sixty experts invited initially to participate in the consensus process 45 (75%) responded to the invitation. The consensus was achieved in 92.6% (63/68) of the CQs. Consensus covers epidemiological aspects of GBC, early, incidental and advanced GBC management, definitions for radical GBC resections, the extent of liver resection, lymph node dissection, and definitions of borderline resectable and locally advanced GBC. Conclusions: This is the first international Delphi consensus on GBC. These recommendations provide uniform terminology and practical clinical guidelines on the current management of GBC. Unresolved contentious issues like borderline resectable/locally advanced GBC need to be addressed by future clinical studies.
AB - Background: The Delphi consensus study was carried out under the auspices of the International and Asia-Pacific Hepato-Pancreato-Biliary Associations (IHPBA-APHPBA) to develop practice guidelines for management of gallbladder cancer (GBC) globally. Method: GBC experts from 17 countries, spanning 6 continents, participated in a hybrid four-round Delphi consensus development process. The methodology involved email, online consultations, and in-person discussions. Sixty eight clinical questions (CQs) covering various domains related to GBC, were administered to the experts. A consensus recommendation was accepted only when endorsed by more than 75% of the participating experts. Results: Out of the sixty experts invited initially to participate in the consensus process 45 (75%) responded to the invitation. The consensus was achieved in 92.6% (63/68) of the CQs. Consensus covers epidemiological aspects of GBC, early, incidental and advanced GBC management, definitions for radical GBC resections, the extent of liver resection, lymph node dissection, and definitions of borderline resectable and locally advanced GBC. Conclusions: This is the first international Delphi consensus on GBC. These recommendations provide uniform terminology and practical clinical guidelines on the current management of GBC. Unresolved contentious issues like borderline resectable/locally advanced GBC need to be addressed by future clinical studies.
KW - Cancer
KW - Gallbladder
KW - International and Asia-Pacific Hepato-Pancreato-Biliary Associations
KW - Clinical guidelines
UR - http://www.scopus.com/inward/record.url?scp=85200910195&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2024.07.411
DO - 10.1016/j.hpb.2024.07.411
M3 - Article
AN - SCOPUS:85200910195
SN - 1365-182X
VL - 26
SP - 1311
EP - 1326
JO - HPB
JF - HPB
IS - 11
ER -
