TY - JOUR
T1 - Immediate early genes in blood pressure regulation
AU - Minson, J. B.
AU - Arnolda, L. F.
AU - Llewellyn-Smith, I. J.
AU - Pilowsky, P. M.
AU - Suzuki, S.
AU - Chalmers, J. P.
PY - 1996
Y1 - 1996
N2 - The immediate early genes c-fos and c-jun are transcription regulating factors. c-fos expression is widely used as a marker of neuronal activation and has been used in this study to identify those neurons, presumably vasomotor neurons, that are activated after interventions that alter blood pressure. c-fos and c-jun are expressed in the rostral ventral medulla (RVM) when the tonically active inhibitory inputs to the RVM are removed, either acutely or chronically, as in the SHR model of genetic hypertension. The injection of antisense oligonucleotide complementary to c-fos mRNA in the RVM attenuates the expression of c-fos, lowers resting blood pressure and attenuates blood pressure responses that are evoked via RVM mechanisms. These studies suggest a link between immediate early gene expression in neurons in the RVM and the regulation of blood pressure. c-fos could have an important role in regulating the activity of these central cardiovascular neurons. The role of the immediate early gene c-jun in cardiovascular control remains to be elucidated.
AB - The immediate early genes c-fos and c-jun are transcription regulating factors. c-fos expression is widely used as a marker of neuronal activation and has been used in this study to identify those neurons, presumably vasomotor neurons, that are activated after interventions that alter blood pressure. c-fos and c-jun are expressed in the rostral ventral medulla (RVM) when the tonically active inhibitory inputs to the RVM are removed, either acutely or chronically, as in the SHR model of genetic hypertension. The injection of antisense oligonucleotide complementary to c-fos mRNA in the RVM attenuates the expression of c-fos, lowers resting blood pressure and attenuates blood pressure responses that are evoked via RVM mechanisms. These studies suggest a link between immediate early gene expression in neurons in the RVM and the regulation of blood pressure. c-fos could have an important role in regulating the activity of these central cardiovascular neurons. The role of the immediate early gene c-jun in cardiovascular control remains to be elucidated.
KW - antisense oligonucleotide
KW - c-fos
KW - c-jun
KW - rostral ventral medulla
KW - vasomotor
UR - http://www.scopus.com/inward/record.url?scp=0029960750&partnerID=8YFLogxK
U2 - 10.3109/10641969609088963
DO - 10.3109/10641969609088963
M3 - Article
C2 - 8743021
AN - SCOPUS:0029960750
SN - 1064-1963
VL - 18
SP - 279
EP - 290
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 3-4
ER -