Immune and inflammatory responses in sudden infant death syndrome

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Infancy is a time of unparalleled infection exposure. Coming from the privilege of the uterus, the newborn infant must make appropriate immune responses following infection that eliminates the infection but protects the host. There is evidence that in sudden infant death syndrome (SIDS) subjects there is a background of recent 'trivial' infection and immunological/inflammatory reactivity. This immunological/inflammatory reactivity is seen in enhanced pulmonary immunoglobulins and T-cell activation. It may be that in certain SIDS cases a trivial infection triggers an exaggerated inflammatory response, inducing cytokine cascades and eventual demise of the infant. Copyright (C) 1999 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalFems Immunology and Medical Microbiology
Issue number1-2
Publication statusPublished - Aug 1999
Externally publishedYes


  • Immune
  • Immunoglobulin
  • Respiratory virus
  • Sudden infant death syndrome
  • T cell


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