TY - JOUR
T1 - Immune checkpoints in rheumatoid arthritis
T2 - progress and promise
AU - Small, Annabelle
AU - Lowe, Katie
AU - Wechalekar, Mihir D.
PY - 2023/11/24
Y1 - 2023/11/24
N2 - Rheumatoid arthritis (RA) is one of the most prevalent autoimmune inflammatory conditions, and while the mechanisms driving pathogenesis are yet to be completely elucidated, self-reactive T cells and immune checkpoint pathways have a clear role. In this review, we provide an overview of the importance of checkpoint pathways in the T cell response and describe the involvement of these in RA development and progression. We discuss the relationship between immune checkpoint therapy in cancer and autoimmune adverse events, draw parallels with the involvement of immune checkpoints in RA pathobiology, summarise emerging research into some of the lesser-known pathways, and the potential of targeting checkpoint-related pathways in future treatment approaches to RA management.
AB - Rheumatoid arthritis (RA) is one of the most prevalent autoimmune inflammatory conditions, and while the mechanisms driving pathogenesis are yet to be completely elucidated, self-reactive T cells and immune checkpoint pathways have a clear role. In this review, we provide an overview of the importance of checkpoint pathways in the T cell response and describe the involvement of these in RA development and progression. We discuss the relationship between immune checkpoint therapy in cancer and autoimmune adverse events, draw parallels with the involvement of immune checkpoints in RA pathobiology, summarise emerging research into some of the lesser-known pathways, and the potential of targeting checkpoint-related pathways in future treatment approaches to RA management.
KW - co-stimulatory pathways
KW - CTLA-4
KW - immune checkpoints
KW - PD-1
KW - rheumatoid arthritis
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=85178954214&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/2004839
U2 - 10.3389/fimmu.2023.1285554
DO - 10.3389/fimmu.2023.1285554
M3 - Review article
AN - SCOPUS:85178954214
SN - 1664-3224
VL - 14
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1285554
ER -